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РЖ ВИНИТИ 76 (BI28) 96.04-04Н3.235

Usui, Hiroko.
Evaluation of ricin A chain-containing immunotoxins directed against glycolipid and glycoprotein on mouse lymphoma cells [Text] / Hiroko Usui, Sen-Itiron Hakomori // Acta med. Okajama. - 1994. - Vol. 48, N 6. - P305-309 . - ISSN 0386-300X
Перевод заглавия: Оценка иммунотоксинов содержащих цепи рицина-А, направленного на гликолипиды и гликопротеины клеток лимфомы мышей
Аннотация: Immunotoxins composed of monoclonal antibodies (mAbs) and various toxins have been developed for the treatment of malignancies. We investigated the efficacy of three ricin toxin A-chain (RTA)-containing immunotoxins (ITs) conjugated from mAbs which recognize glycolipid asialo-GM2 and glycoprotein H-2{d}. These ITs retained the same immunoreactivity with mAbs. We evaluated the cytotoxicity of these ITs against mouse lymphoma cell L51 78Y variants showing high (AA12,CC9) and low (27AV) expression of asialo-GM2. Anti-H-2{d}-RTA IT had the strongest cytotoxicity for all cell lines. Anti-asialo-GM2 (IgM)-RTA IT had stronger cytotoxicity than anti-asialo-GM2 (IgG3)-RTA IT. Anti-asialo-GM2-RTA ITs had different cytotoxicity against AA12 and CC9 cells. The establishment of appropriate anti-glycolipid mAbs may lead to effective immunotargeting therapy. Библ. 22

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.55.11.17
Рубрики: ОПУХОЛИ ЭКСПЕРИМЕНТАЛЬНЫЕ
ЛИМФОМЫ
ИММУНОТЕРАПИЯ
ИММУНОТОКСИНЫ
РИЦИН
ЦЕПЬ А

Доп.точки доступа:
Hakomori, Sen-Itiron

РЖ ВИНИТИ 76 (BI29) 96.04-04Н1.433

Usui, Hiroko.
Evaluation of ricin A chain-containing immunotoxins directed against glycolipid and glycoprotein on mouse lymphoma cells [Text] / Hiroko Usui, Sen-Itiron Hakomori // Acta med. Okajama. - 1994. - Vol. 48, N 6. - P305-309 . - ISSN 0386-300X
Перевод заглавия: Оценка иммунотоксинов содержащих цепи рицина-А, направленного на гликолипиды и гликопротеины клеток лимфомы мышей
Аннотация: Immunotoxins composed of monoclonal antibodies (mAbs) and various toxins have been developed for the treatment of malignancies. We investigated the efficacy of three ricin toxin A-chain (RTA)-containing immunotoxins (ITs) conjugated from mAbs which recognize glycolipid asialo-GM2 and glycoprotein H-2{d}. These ITs retained the same immunoreactivity with mAbs. We evaluated the cytotoxicity of these ITs against mouse lymphoma cell L51 78Y variants showing high (AA12,CC9) and low (27AV) expression of asialo-GM2. Anti-H-2{d}-RTA IT had the strongest cytotoxicity for all cell lines. Anti-asialo-GM2 (IgM)-RTA IT had stronger cytotoxicity than anti-asialo-GM2 (IgG3)-RTA IT. Anti-asialo-GM2-RTA ITs had different cytotoxicity against AA12 and CC9 cells. The establishment of appropriate anti-glycolipid mAbs may lead to effective immunotargeting therapy. Библ. 22

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.23.05
Рубрики: ОПУХОЛИ ЭКСПЕРИМЕНТАЛЬНЫЕ
ЛИМФОМЫ
ИММУНОТЕРАПИЯ
ИММУНОТОКСИНЫ
РИЦИН
ЦЕПЬ А

Доп.точки доступа:
Hakomori, Sen-Itiron

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