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РЖ ВИНИТИ 34 (BI39) 95.11-04К1.258

Cross-reactive trinitrophenylated peptides as antigens for class II major histocompatibility complex-restricted T cells and inducers of contact sensitivity in mice. Limited T cell receptor repertoire [Text] / Jochen Kohler [et al.] // Eur. J. Immunol. - 1995. - Vol. 25, N 1. - P92-101 . - ISSN 0014-2980
Перевод заглавия: Перекрестно реагирующие трифенилированные пептиды как антигены для ограниченных по классу II главного комплекса гистосовместимости Т-лимфоцитов и как индукторы контактной чувствительности у мышей. Ограниченный набор Т-клеточных рецепторов
Аннотация: The induction of contact sensitivity in mice by hapten reagents such as trinitrochlorobenzene (TNCB) involves the activation of class II major histocompatibility complex (MHC)-restricted, hapten-specific, CD4{+} T cells. Reports from different laboratories have indicated that the relevant antigenic epitopes in such reactions might include hapten conjugated. MHC class II-associated peptides. This study for the first time directly demonstrates that hapten-peptides account for the majority of determinants recognized by trinitrophenyl (TNP)-specific CD4{+} T lymphocytes. The sequences of those TNP carrier peptides do not have to be related to mouse proteins. Thus, we show that TNP-modified peptides derived from mouse IgG, pigeon cytochrome c or staphylococcal nuclease known to bind to I-A{b} or from 'лямбда' repressor with specificity to I-A{b} as well as TNP-proteins such as bovine serum albumin, ovalbumin or keyhole limpet hemocyanin all create class II-restricted hapten determinants for a number of TNP-specific T cell clones and hybridomas. All of these cells were induced with cells modified by trinitrobenzene sulfonic acid (TNBS). In addition, we present arguments indicating that individual TNP-specific helper T cells may cross-react with different TNP-peptides bound to identical class II molecules. Chemical treatment of antigen-presenting cells with TNCB or TNBS may thus result in a limited number of particularly repetitive immunodominant hapten epitopes. Immunodominant epitopes were also indicated by an overrepresentation of the TCR elements V'бета'2 and V'альфа'10 in I-A{b}/TNP-specific T cells. Most importantly, however, we demonstrate that TNP attached to lysine 97 in the staphylococcal nuclease peptide 93-105 (i.e. a clearly "non-self" sequence) is able to prime mice for subsequent elicitation of contact sensitivity by TNCB in the absence of foreign protein. We take this to indicate that those TNP-peptide determinants defined by us as immuno-dominant are responsible for the induction of contact sensitivity to haptens. Германия, Max-Planck-Inst. Immunobiol., Freiburg. Библ. 66

ГРНТИ	34.43.29

ВИНИТИ 341.43.29.11
Рубрики: ЛИМФОЦИТЫ T
ОГРАНИЧЕНИЕ ПО ГКГС КЛАССУ II
ТРИФЕНИЛИРОВАННЫЕ ПЕПТИДЫ
АНТИГЕННОСТЬ
ГИПЕРЧУВСТВИТЕЛЬНОСТЬ ЗАМЕДЛЕННОГО ТИПА
МЫШИ

Доп.точки доступа:
Kohler, Jochen; Martin, Stefan; Pflugfelder, Ulrike; Ruh, Helga; Vollmer, Jorg; Weltzien, Hans Ulrich

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