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РЖ ВИНИТИ 76 (BI29) 96.11-04Н1.84

The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation [Text] / Michael C. Lill [et al.] // Blood. - 1995. - Vol. 85, N 2. - P692-697 . - ISSN 0006-4971
Перевод заглавия: Роль гомеобокс-содержащего гена HOX B7 в миеломоноцитарной дифференцировке [клеток] человека
Аннотация: Homeobox genes encode transcription factors known to be important morphogenic regulators during embryogenesis. An increasing body of work implies a role for homeobox genes in both hematopoiesis and oncogenesis. We have analyzed the role of the homeobox gene, HOX B7, in the program of differentiation of the biphenotypic myeloid cell line, HL60. Induction of monocytic differentiation in HL-60 cells by vitamin D[3] resulted in rapid expression of HOX B7 mRNA, but stimulation with phorbol ester or dimethyl sulfoxide (DMSO) did not. Constitutive overexpression of HOX B7 in the HL60 cell line inhibited the granulocytic differentiation associated with stimulation with DMSO or retinoic acid, but had no effect on the monocytic differentiation induced by vitamin D[3]. Normal human monocytes do not constitutively express HOX B7, nor are they able to be induced to do so by stimulation with colony-stimulating factor 1 (CSF-1) and gamma interferon (IFN'гамма'), or with vitamin D[3] and lipopolysaccharide. Human bone marrow (BM) cells were found to express HOX B7 in response to granulocyte-macrophage CSF (GM-CSF) and antisense oligonucleotides directed against HOX B7 inhibited the formation of colonies derived from GM-CSF-stimulated BM. These data suggest a critical role for HOX B7 in myelomonocytic differentiation. США, [Gasson Judith C.] Div. Hematology-Oncology, 11-934 Factor, Dep. Medicine, UCLA School of Medicine, Los Angeles, CA 90024-1678. Библ. 16

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.03.25.15
Рубрики: ДИФФЕРЕНЦИРОВКА
МИЕЛОМОНОЦИТАРНАЯ
ГЕНЫ
ГЕН HOX B7
ФАКТОРЫ РОСТА
ИНТЕРФЕРОНЫ
МОНОЦИТЫ

Доп.точки доступа:
Lill, Michael C.; Fuller, John F.; Herzig, Ron; Crooks, Gay M.; Gasson, Judith C.

РЖ ВИНИТИ 34 (BI49) 97.01-04Я6.306

The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation [Text] / Michael C. Lill [et al.] // Blood. - 1995. - Vol. 85, N 2. - P692-697 . - ISSN 0006-4971
Перевод заглавия: Роль гомеобокс-содержащего гена HOX B7 в миеломоноцитарной дифференцировке [клеток] человека
Аннотация: Homeobox genes encode transcription factors known to be important morphogenic regulators during embryogenesis. An increasing body of work implies a role for homeobox genes in both hematopoiesis and oncogenesis. We have analyzed the role of the homeobox gene, HOX B7, in the program of differentiation of the biphenotypic myeloid cell line, HL60. Induction of monocytic differentiation in HL-60 cells by vitamin D[3] resulted in rapid expression of HOX B7 mRNA, but stimulation with phorbol ester or dimethyl sulfoxide (DMSO) did not. Constitutive overexpression of HOX B7 in the HL60 cell line inhibited the granulocytic differentiation associated with stimulation with DMSO or retinoic acid, but had no effect on the monocytic differentiation induced by vitamin D[3]. Normal human monocytes do not constitutively express HOX B7, nor are they able to be induced to do so by stimulation with colony-stimulating factor 1 (CSF-1) and gamma interferon (IFN'гамма'), or with vitamin D[3] and lipopolysaccharide. Human bone marrow (BM) cells were found to express HOX B7 in response to granulocyte-macrophage CSF (GM-CSF) and antisense oligonucleotides directed against HOX B7 inhibited the formation of colonies derived from GM-CSF-stimulated BM. These data suggest a critical role for HOX B7 in myelomonocytic differentiation. США, [Gasson Judith C.] Div. Hematology-Oncology, 11-934 Factor, Dep. Medicine, UCLA School of Medicine, Los Angeles, CA 90024-1678. Библ. 16

ГРНТИ	34.19.19

ВИНИТИ 341.19.19.15
Рубрики: ДИФФЕРЕНЦИРОВКА
МИЕЛОМОНОЦИТАРНАЯ
ГЕНЫ
ГЕН HOX B7
ФАКТОРЫ РОСТА
ИНТЕРФЕРОНЫ
МОНОЦИТЫ

Доп.точки доступа:
Lill, Michael C.; Fuller, John F.; Herzig, Ron; Crooks, Gay M.; Gasson, Judith C.

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