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РЖ ВИНИТИ 76 (BI28) 97.08-04Н3.219

The effects of Ribavirin on the GTP level and the VIP receptor dynamic of human IGR39 cells [Text] / Francis Foucher [et al.] // J. Receptor and Signal Transduct. Res. - 1996. - Vol. 16, N 1-2. - P39-58 . - ISSN 1079-9893
Перевод заглавия: Влияние рибавирина на уровень GTP и динамику рецепторов VIP клеток человека IGR39
Аннотация: GTP is one of the major cellular molecules involved in fundamental functions of cell life. Ribavirin, an antiviral and antitumoral agent, the primary site of action of which is the IMP deshydrogenase, was used in order to depress the intracellular GTP level. Consequential effects were tested on the property and dynamic of the VIP receptor on human melanoma IGR 39 cells. A concentration of 100 'мю'M of Ribavirin reduced the intracellular GTP level by more than 60% and induced a reversible growth arrest. Nevertheless this drug displayed no effect on: the VIP binding parameters (K[d] and B[max]) of both high and low affinity receptors; the cycling of the VIP receptor; the basal and VIP-stimulated cAMP production and the subcellular GTP distribution. It was showed that Ribavirin, in the range of concentrations used, is very efficient to inhibit GTP synthesis in the human melanoma cell line IGR 39 and its growth, without affecting VIP receptor functions. Библ. 33

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.55.07.11.35
Рубрики: КУЛЬТУРА КЛЕТОК
МЕЛАНОМА
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА
ПРОТИВОВИРУСНЫЕ СРЕДСТВА
РИБАВИРИН
МЕХАНИЗМ ДЕЙСТВИЯ
ГТФ
ВАЗОАКТИВНЫЙ ИНТЕСТИНАЛЬНЫЙ ПЕПТИД И VIP
IN VITRO

Доп.точки доступа:
Foucher, Francis; Forget, Pierre; Bellan, Catherine; Marvaldi, Jacques; Champion, Serge; Pichon, Jacques

РЖ ВИНИТИ 76 (BI29) 97.09-04Н1.326

The effects of Ribavirin on the GTP level and the VIP receptor dynamic of human IGR39 cells [Text] / Francis Foucher [et al.] // J. Receptor and Signal Transduct. Res. - 1996. - Vol. 16, N 1-2. - P39-58 . - ISSN 1079-9893
Перевод заглавия: Влияние рибавирина на уровень GTP и динамику рецепторов VIP клеток человека IGR39
Аннотация: GTP is one of the major cellular molecules involved in fundamental functions of cell life. Ribavirin, an antiviral and antitumoral agent, the primary site of action of which is the IMP deshydrogenase, was used in order to depress the intracellular GTP level. Consequential effects were tested on the property and dynamic of the VIP receptor on human melanoma IGR 39 cells. A concentration of 100 'мю'M of Ribavirin reduced the intracellular GTP level by more than 60% and induced a reversible growth arrest. Nevertheless this drug displayed no effect on: the VIP binding parameters (K[d] and B[max]) of both high and low affinity receptors; the cycling of the VIP receptor; the basal and VIP-stimulated cAMP production and the subcellular GTP distribution. It was showed that Ribavirin, in the range of concentrations used, is very efficient to inhibit GTP synthesis in the human melanoma cell line IGR 39 and its growth, without affecting VIP receptor functions. Библ. 33

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.19.11.07
Рубрики: КУЛЬТУРА КЛЕТОК
МЕЛАНОМА
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА
ПРОТИВОВИРУСНЫЕ СРЕДСТВА
РИБАВИРИН
МЕХАНИЗМ ДЕЙСТВИЯ
ГТФ
ВАЗОАКТИВНЫЙ ИНТЕСТИНАЛЬНЫЙ ПЕПТИД И VIP
IN VITRO

Доп.точки доступа:
Foucher, Francis; Forget, Pierre; Bellan, Catherine; Marvaldi, Jacques; Champion, Serge; Pichon, Jacques

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