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РЖ ВИНИТИ 34 (BI49) 96.02-04Я6.464

Motyka, B.
Rescue of ileal Peyer's patch B cells from apoptosis is associated with the induction of Bcl-2 expression [Text] / B. Motyka, J. D. Reynolds // Immunology. - 1995. - Vol. 84, N 3. - P383-387 . - ISSN 0019-2805
Перевод заглавия: Спасение В клеток пейеровых бляшек подвздошной кишки от апоптоза связано с индукцией экспрессии Bcl-2
Аннотация: The major site of B-cell genesis in the sheep is the ileal Peyer's patch (PP). The B cells in the ileal PP undergo both extensive proliferation and massive death th association with an ongoing diversification of the immunoglobulin repertoire by somatic hypermutation. Most, if not all, the B-cell death in the ileal PP is due to apoptosis. When placed in culture, ileal PP B cells undergo rapid apoptosis. Here, we investigated the expression of the proto-oncogene bcl-2 in ileal PP cells in situ and in culture. Bcl-2 expression has been correlated with the prevention of apoptosis in many cell types. Western blotting, using anti-Bcl-2 monoclonal antibodies, revealed that a Bcl-2-reactive protein of 26 000 MW was expressed in ileal mesenteric lymph node cells, splenocytes and thymocytes from sheep, but was barely detectable in ileal PP B cells in situ or in culture. However, Bcl-2 expression could be markedly induced in ileal PP B cells cultured with phorbol ester and Ca{2+} ionophore, a procedure that is known to rescue these cells from apoptosis. We hypothesize that those few B cells that survive a selection event in the ileal PP may begin to express elevated levels of Bcl-2 as they escape from the apoptotic pathway. Канада, [J. D. R.], Dep. Med. Physiol., Univ. Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1. Библ. 33

ГРНТИ	34.19.19

ВИНИТИ 341.19.19.23
Рубрики: АПОПТОЗ
В-КЛЕТКИ
ЭКСПРЕССИЯ ОНКОГЕНА BCL-2
ПОДВЗДОШНАЯ КИШКА
ПЕЙЕРОВЫ БЛЯШКИ

Доп.точки доступа:
Reynolds, J.D.

РЖ ВИНИТИ 34 (BI39) 96.02-04К1.155

Motyka, B.
Rescue of ileal Peyer's patch B cells from apoptosis is associated with the induction of Bcl-2 expression [Text] / B. Motyka, J. D. Reynolds // Immunology. - 1995. - Vol. 84, N 3. - P383-387 . - ISSN 0019-2805
Перевод заглавия: Спасение В клеток пейеровых бляшек подвздошной кишки от апоптоза связано с индукцией экспрессии Bcl-2
Аннотация: The major site of B-cell genesis in the sheep is the ileal Peyer's patch (PP). The B cells in the ileal PP undergo both extensive proliferation and massive death th association with an ongoing diversification of the immunoglobulin repertoire by somatic hypermutation. Most, if not all, the B-cell death in the ileal PP is due to apoptosis. When placed in culture, ileal PP B cells undergo rapid apoptosis. Here, we investigated the expression of the proto-oncogene bcl-2 in ileal PP cells in situ and in culture. Bcl-2 expression has been correlated with the prevention of apoptosis in many cell types. Western blotting, using anti-Bcl-2 monoclonal antibodies, revealed that a Bcl-2-reactive protein of 26 000 MW was expressed in ileal mesenteric lymph node cells, splenocytes and thymocytes from sheep, but was barely detectable in ileal PP B cells in situ or in culture. However, Bcl-2 expression could be markedly induced in ileal PP B cells cultured with phorbol ester and Ca{2+} ionophore, a procedure that is known to rescue these cells from apoptosis. We hypothesize that those few B cells that survive a selection event in the ileal PP may begin to express elevated levels of Bcl-2 as they escape from the apoptotic pathway. Канада, [J. D. R.], Dep. Med. Physiol., Univ. Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1. Библ. 33

ГРНТИ	34.43.29

ВИНИТИ 341.43.29.11
Рубрики: АПОПТОЗ
В-КЛЕТКИ
ЭКСПРЕССИЯ ОНКОГЕНА BCL-2
ПОДВЗДОШНАЯ КИШКА
ПЕЙЕРОВЫ БЛЯШКИ

Доп.точки доступа:
Reynolds, J.D.

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