СибНСХБ

Вид поиска

Область поиска

Найдено в других БД

Формат представления найденных документов:
библиографическое описание	краткий	полный

Поисковый запрос: (<.>S=ТИПЫ ПЕРЕНОСЧИКОВ<.>)

Общее количество найденных документов : 1

РЖ ВИНИТИ 34 (BI24) 97.03-04М3.181

Ginsberg, Stephen D.
Regional deafferentation down-regulates subtypes of glutamate transporter proteins [Text] / Stephen D. Ginsberg, Lee J. Martin, Jeffrey D. Rothstein // J. Neurochem. - 1995. - Vol. 65, N 6. - P2800-2803 . - ISSN 0022-3042
Перевод заглавия: Регионарная деафферентация понижающе регулирует подтипы белков-переносчиков глутамата
Аннотация: Low extracellular glutamate content is maintained primarily by high-affinity sodium-dependent glutamate transport. Three glutamate transporter proteins have been cloned: GLT-1 and GLAST are astroglial, whereas EAAC1 is neuronal. The effects of axotomy on glutamate transporter expression was evaluated in adult rats following unilateral fimbria-fornix and corticostriatal lesions. The hippocampus and striatum were collected at 3, 7, 14, and 30 days postlesion. Homogenates were immunoblotted using antibodies directed against GLT-1, GLAST, EAAC1, and glial fibrillary acidic protein and assayed for glutamate transport by D-[{3}H]aspartate binding. GLT-1 immunoreactivity was decreased within the ipsilateral hippocampus and striatum at 14 days postlesion. GLAST immunoreactivity was decreased within the ipsilateral hippocampus and striatum at 7 and 14 days postlesion. No alterations in EAAC1 immunoreactivity were observed. D-[{3}H]Aspartate binding was decreased at 14 days postlesion within the ipsilateral hippocampus and at 7 and 14 days postlesion within the ipsilateral striatum. By 30 days postlesion, glutamate transporters and D-[{3}H]aspartate binding returned to control levels. This study demonstrates the downregulation of primarily glial, and not neuronal, glutamate transporters following regional disconnection. Библ. 25

ГРНТИ	34.39.15

ВИНИТИ 341.39.15.37.11.17
Рубрики: ГЛУТАМАТ
ТРАНСПОРТНЫЕ БЕЛКИ
ТИПЫ ПЕРЕНОСЧИКОВ
КЛОНИРОВАНИЕ
ТРАНСЕКЦИЯ ФИМБРИЯ-ФОРНЕКС
ДЕГЕНЕРАЦИЯ КОРТИКО-СТРИАТУМА
КРЫСЫ

Доп.точки доступа:
Martin, Lee J.; Rothstein, Jeffrey D.

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

rtvarBDview(" результаты поиска","20190607010228","4682442");

Вид поиска