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РЖ ВИНИТИ 34 (BI48) 96.10-04Т2.418

The hematoregulatory peptide, SK&F 107647, inb combination with antifungal therapy in murine Candida albicans infections [Text] : [Pap.] IMC'5: 5th Int. Mycol. Congr., Vancouver, Aug. 14-21, 1994 / Peter l. DeMarsh [et al.] // Can. J. Bot. - 1995. - Vol. 73, Suppl. 1 Sec. E-H. - P1199-1205 . - ISSN 0008-4026
Перевод заглавия: Комбинированное [воздействие] гематорегуляторного пептида SK&F 107647 и противогрибковых средств на мышей, инфицированных Candida albicans
Аннотация: SK&F 107647, a novel synthetic low molecular weight peptide, has been shown to be a potent hematoregulatory agent. It was previously demonstrated that SK&F 107647 administration can prolong survival in both immunosuppressed and normal mice challenged with the opportunistic fungal pathogen Candida albicans. Additionally, it was determined the effect of prophylactic SK&F 107647 treatment combined with conventional antifungal therapy on the survival of mice challenged with a lethal dose of C. albicans.Prophylactic treatment with SK&F 107647 or therapeutic treatment with the antifungals fluconazole or amphotericin B significantly increased the survival rates of immunosuppressed mice challenged with a lethal dose of C. albicans. However, the combination of SK&F 107647 treatment followed by antifungal therapy resulted in statistically significant increases in survival over that observed with either therapy alone. These results indicated that the hematoregulatory factor(s) elicited by SK&F 107647 enhance the survival of mice treated with conventional therapies in a model of experimental systemic candidiasis. США, Dep. Anti-Infectives, L-523, Smithkline Beecham Pharmaceuticals, King of Prussia, PA 19406. Библ. 44

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.53
Рубрики: ПРОТИВОГРИБКОВЫЕ СРЕДСТВА
ФЛУКОНАЗОЛ
АМФОТЕРИЦИН B
СИНТЕТИЧЕСКИЙ НИЗКОМОЛЕКУЛЯРНЫЙ ПЕПТИД SK&F
КОМБИНИРОВАННОЕ ВОЗДЕЙСТВИЕ
АКТИВНОСТЬ
CANDIDA ALBICANS
IN VIVO
МЫШИ

Доп.точки доступа:
DeMarsh, Peter l.; Sucoloski, Scott K.; Frey, Carrie L.; Bhatnagar, Pradip K.; Koltin, Yigal; Actor, Paul; Pelus, Louis M.; Petteway, Staphen R.

РЖ ВИНИТИ 34 (BI14) 97.01-04Б4.240

The hematoregulatory peptide, SK&F 107647, inb combination with antifungal therapy in murine Candida albicans infections [Text] : [Pap.] IMC'5: 5th Int. Mycol. Congr., Vancouver, Aug. 14-21, 1994 / Peter l. DeMarsh [et al.] // Can. J. Bot. - 1995. - Vol. 73, Suppl. 1 Sec. E-H. - P1199-1205 . - ISSN 0008-4026
Перевод заглавия: Комбинированное [воздействие] гематорегуляторного пептида SK&F 107647 и противогрибковых средств на мышей, инфицированных Candida albicans
Аннотация: SK&F 107647, a novel synthetic low molecular weight peptide, has been shown to be a potent hematoregulatory agent. It was previously demonstrated that SK&F 107647 administration can prolong survival in both immunosuppressed and normal mice challenged with the opportunistic fungal pathogen Candida albicans. Additionally, it was determined the effect of prophylactic SK&F 107647 treatment combined with conventional antifungal therapy on the survival of mice challenged with a lethal dose of C. albicans.Prophylactic treatment with SK&F 107647 or therapeutic treatment with the antifungals fluconazole or amphotericin B significantly increased the survival rates of immunosuppressed mice challenged with a lethal dose of C. albicans. However, the combination of SK&F 107647 treatment followed by antifungal therapy resulted in statistically significant increases in survival over that observed with either therapy alone. These results indicated that the hematoregulatory factor(s) elicited by SK&F 107647 enhance the survival of mice treated with conventional therapies in a model of experimental systemic candidiasis. США, Dep. Anti-Infectives, L-523, Smithkline Beecham Pharmaceuticals, King of Prussia, PA 19406. Библ. 44

ГРНТИ	34.27.29

ВИНИТИ 341.27.29.21.09
Рубрики: ПРОТИВОГРИБКОВЫЕ СРЕДСТВА
ФЛУКОНАЗОЛ
АМФОТЕРИЦИН B
СИНТЕТИЧЕСКИЙ НИЗКОМОЛЕКУЛЯРНЫЙ ПЕПТИД SK&F
КОМБИНИРОВАННОЕ ВОЗДЕЙСТВИЕ
АКТИВНОСТЬ
CANDIDA ALBICANS
IN VIVO
МЫШИ

Доп.точки доступа:
DeMarsh, Peter l.; Sucoloski, Scott K.; Frey, Carrie L.; Bhatnagar, Pradip K.; Koltin, Yigal; Actor, Paul; Pelus, Louis M.; Petteway, Staphen R.

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