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РЖ ВИНИТИ 34 (BI39) 95.09-04К1.112

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: Implications for graft-versus-host disease [Text] / S. Burrows [et al.] // J. Exp. Med. - 1994. - Vol. 179, N 4. - P1155-1161 . - ISSN 0022-1007
Перевод заглавия: Аллогенный ответ у человека доминируется цитотоксическими лимфоцитами (ЦТЛ), перекрестно реагирующими с единственным эпитопом для ЦТЛ вируса Эпштейна-Барр. Значение для болезни трансплантат против хозяина
Аннотация: The phenomenon of T cell allorecognition is difficult to accommodate within the framework of a T cell repertoire positively selected in the thymus, unless allorecognition results from the cross-reactions of self-major histocompatibility complex restricted T cells. Herein, we demonstrate the dual specificity of cytotoxic T lymphocyte (CTL) clones for the immunodominant Epstein-Barr virus (EBV) epitope FLRGRAYGL, presented on HLA-B8, and the alloantigen HLA-B{*}4402. CTL which recognized peptide FLRGRAYGL in association with HLA-B8 could be reactivated in vitro from healthy individuals who had been exposed previously to EBV, using stimulator cells expressing the cross-reacting alloantigen HLA-B{*}4402. Limiting dilution analysis of the alloresponse to HLA-B{*}4402 in eight healthy individuals revealed that HLA-B8{-}, EBV-sero{-} donors had higher CTL precursor frequencies for alloantigen HLA-B{*}4402 than EBV-sero{-} control donors. It is surprising that the majority (65-100%) of anti-HLA-B{*}4402 CTL, generated in limiting dilution mixed lymphocyte reactions between responder cells from HLA-B8{+}, EBV-sero{+} individuals and HLA-B{*}4402{+} stimulators, also recognized the EBV CTL epitope FLRGRAYGL/HLA-B8. In contrast to previous studies showing extensive diversity in the T cell repertoire against individual alloantigens, these data demonstrate that the response to an alloantigen can be dominated by CTL cross-reactive with a single viral epitope, thus illustrating a possible mechanism for the frequent clinical association between herpesvirus exposure and graftversus-host disease after bone marrow transplants. Австралия, Queensland Inst. Med. Res., Banoroft Ctr., Herston, Brisbane. Библ. 34

ГРНТИ	34.43.29

ВИНИТИ 341.43.29.11
Рубрики: ЛИМФОЦИТЫ Т ЦИТОТОКСИЧЕСКИЕ
РОЛЬ В АЛЛОИММУНИЗАЦИИ
ПЕРЕКРЕСТНАЯ РЕАКЦИЯ
АНТИГЕНЫ ГКГС
АНТИГЕНЫ ВИРУСА ЭПШТЕЙНА-БАРР
ЭПИТОПЫ МИШЕНИ
РЕАКЦИЯ ТРАНСПЛАНТАТ ПРОТИВ ХОЗЯИНА
ЧЕЛОВЕК

Доп.точки доступа:
Burrows, S.; Khanna, R.; Burrows, J.M.; Moss, D.J.

РЖ ВИНИТИ 34 (BI11) 95.10-04Б1.209

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: Implications for graft-versus-host disease [Text] / S. Burrows [et al.] // J. Exp. Med. - 1994. - Vol. 179, N 4. - P1155-1161 . - ISSN 0022-1007
Перевод заглавия: Аллогенный ответ у человека доминируется цитотоксическими лимфоцитами (ЦТЛ), перекрестно реагирующими с единственным эпитопом для ЦТЛ вируса Эпштейна-Барр. Значение для болезни трансплантат против хозяина
Аннотация: The phenomenon of T cell allorecognition is difficult to accommodate within the framework of a T cell repertoire positively selected in the thymus, unless allorecognition results from the cross-reactions of self-major histocompatibility complex restricted T cells. Herein, we demonstrate the dual specificity of cytotoxic T lymphocyte (CTL) clones for the immunodominant Epstein-Barr virus (EBV) epitope FLRGRAYGL, presented on HLA-B8, and the alloantigen HLA-B{*}4402. CTL which recognized peptide FLRGRAYGL in association with HLA-B8 could be reactivated in vitro from healthy individuals who had been exposed previously to EBV, using stimulator cells expressing the cross-reacting alloantigen HLA-B{*}4402. Limiting dilution analysis of the alloresponse to HLA-B{*}4402 in eight healthy individuals revealed that HLA-B8{-}, EBV-sero{-} donors had higher CTL precursor frequencies for alloantigen HLA-B{*}4402 than EBV-sero{-} control donors. It is surprising that the majority (65-100%) of anti-HLA-B{*}4402 CTL, generated in limiting dilution mixed lymphocyte reactions between responder cells from HLA-B8{+}, EBV-sero{+} individuals and HLA-B{*}4402{+} stimulators, also recognized the EBV CTL epitope FLRGRAYGL/HLA-B8. In contrast to previous studies showing extensive diversity in the T cell repertoire against individual alloantigens, these data demonstrate that the response to an alloantigen can be dominated by CTL cross-reactive with a single viral epitope, thus illustrating a possible mechanism for the frequent clinical association between herpesvirus exposure and graftversus-host disease after bone marrow transplants. Австралия, Queensland Inst. Med. Res., Banoroft Ctr., Herston, Brisbane. Библ. 34

ГРНТИ	34.25.23

ВИНИТИ 341.25.23.02
Рубрики: ЛИМФОЦИТЫ Т ЦИТОТОКСИЧЕСКИЕ
РОЛЬ В АЛЛОИММУНИЗАЦИИ
ПЕРЕКРЕСТНАЯ РЕАКЦИЯ
АНТИГЕНЫ ГКГС
АНТИГЕНЫ ВИРУСНЫЕ
ЭПИТОПЫ МИШЕНИ
РЕАКЦИЯ ТРАНСПЛАНТАТ ПРОТИВ ХОЗЯИНА
ВИРУС ЭПШТЕЙНА-БАРР

Доп.точки доступа:
Burrows, S.; Khanna, R.; Burrows, J.M.; Moss, D.J.

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