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РЖ ВИНИТИ 76 (BI29) 96.06-04Н1.108

Gomez, Manuel.
Expression of 'бета'1 integrin receptors in transformed mouse epidermal keratinocytes: Upregulation of 'альфа'5'бета'1 in spindle carcinoma cells [Text] / Manuel Gomez, Amparo Cano // Mol. Carcinogenes. - 1995. - Vol. 12, N 3. - P153-165 . - ISSN 0899-1987
Перевод заглавия: Экспрессия рецепторов интегрина 'бета'1 в трансформированных эпидермальных кератиноцитах мышей: регуляция 'альфа'5'бета'1 в веретеноподобных клетках карциномы
Аннотация: The adhesive properties and the expression of extracellular matrix receptors of the 'бета'1-integrin subfamily were analyzed in transformed epidermal keratinocyte cell lines of different stages of mouse skin carcinogenesis. One- and two-dimensional analyses of the immunoprecipitates obtained with anti-'бета'1- and specific anti-'альфа'-integrin subunits showed qualitative and quantitative changes in the expression of 'бета'1 integrins by the different cell lines. The polyvalent 'альфа'3'бета'1 integrin was expressed by all analysed cell lines, although the levels detected in undifferentiated spindle CarC cells were lower than those present in the rest of keratinocyte cell lines. In contrast, spindle cells expressed high levels of the specific fibronectin receptor 'альфа'5'бета'1, whereas this integrin was absent or expressed at very reduced levels in the other epithelial cell lines. Expression of 'альфа'5'бета'1 integrin in spindle cells appeared organized in cell-substratum contact areas on spread cells. In addition, high and homogenous expression of 'альфа'5'бета'1 was detected in fully undifferentiated tumors induced in nude mice by three independent spindle cell lines. These results suggest that the expression of 'альфа'5'бета'1 integrin in upregulated during the development of spindle cell carcinomas that occur in the last stages of mouse skin carcinogenesis and can be associated with the acquisition of the fibroblastoid phenotype of spindle cells. On the other hand, expression of the collagen receptor 'альфа'2'бета'1 was demonstrated in a transformed cell line (PDV), and it was apparently also expressed in two other malignant keratinocyte cell lines (PDVC57 and HaCa4). The expression of 'альфа'2'бета'1 was correlated with the increased adhesion to collagen type I and collagen type IV exhibited by the tumorigenic cell lines. Испания, Inst. Invest. Biomed., Consejo Superior Invest. Cien., Dep. Bioquim., Fac. Med., Univ. Autonoma Madrid, Madrid. Библ. 42

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.15.25.07.02
Рубрики: РЕЦЕПТОР ИНТЕГРИНА БЭТА1
ЭКСПРЕССИЯ
КЕРАТИНОЦИТЫ
ЭПИДЕРМАЛЬНЫЕ ТРАНСФОРМИРОВАННЫЕ
РЕГУЛЯЦИЯ 'АЛЬФА'5'БЕТА'1 В ВЕРЕТЕНОПОДОБНЫХ КЛЕТКАХ КАРЦИНОМЫ
МЫШИ

Доп.точки доступа:
Cano, Amparo

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