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РЖ ВИНИТИ 76 (BI28) 97.02-04Н3.243

Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065 [Text] / Gayle E. Woloschak [et al.] // Cancer Res. - 1995. - Vol. 55, N 21. - P4788-4792 . - ISSN 0008-5472
Перевод заглавия: Экспрессия мРНК тимидинкиназы и связанных транскриптов модулируется радиопротектором WR1065
Аннотация: Previous studies have shown that the radioprotector WR1065 protects against mutagenesis across a wide concentration range (i. e., 40 'мю'м to 4 mм) but protects against cell killing by ionizing radiation at concentrations greater than 1 mм. Other work has demonstrated that many genes are induced or repressed after exposure of cells in culture to ionizing radiation, but the actual inducing agents for this gene modulation response are unknown. In these experiments, it was seted out to identify genes that would be modulated in response to two different concentrations of WR1065 (i. e., a lower dose that is incapable of protecting against cell killing but effective in protecting against mutation induction, and a high dose that is effective in protecting against both end points). Using differential display reverse transcription-PCR, it was compared genes expressed in untreated cells to those expressed in cells treated with different concentrations of WR1065 (4 mм or 40 'мю'м) with or without radiation exposure (7.5 Gy). One band, which showed a differential response, was sequenced and found to have homology in the 3'-untranslated region of the mouse thymidine kinase (tk) gene but not identity to the Chinese hamster ovary tk gene. Dot blot and Northern blot analyses confirmed the dfferential display results and also determined that regulation of the tk-like gene is similar to that of tk itself. These experiments estabilished that in Chinese hamster ovary cells, radiation causes a repression in accumulation of tk mRNA and a related tk-like transcript. This repression is made less dramatic by the presence of 40 'мю'м WR1065, and, in fact, expression becomes enhanced when cells are pretreated with 4 mм WR1065. This suggests a role for regulation of tk and its related gene in the survival response of cells after exposure to ionizing radiation. Библ. 46

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.55.13.05
Рубрики: КУЛЬТУРА КЛЕТОК
CHO
ТИМИДИНКИНАЗА
МРНК
ЭКСПРЕССИЯ
ТРАНСКРИПТЫ
РАДИОПРОТЕКТОР WR1065
IN VITRO

Доп.точки доступа:
Woloschak, Gayle E.; Paunesku, Tatjana; Chang-Liu, Chin-Mei; Grdina, David J.

РЖ ВИНИТИ 76 (BI29) 97.02-04Н1.352

Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065 [Text] / Gayle E. Woloschak [et al.] // Cancer Res. - 1995. - Vol. 55, N 21. - P4788-4792 . - ISSN 0008-5472
Перевод заглавия: Экспрессия мРНК тимидинкиназы и связанных транскриптов модулируется радиопротектором WR1065
Аннотация: Previous studies have shown that the radioprotector WR1065 protects against mutagenesis across a wide concentration range (i. e., 40 'мю'м to 4 mм) but protects against cell killing by ionizing radiation at concentrations greater than 1 mм. Other work has demonstrated that many genes are induced or repressed after exposure of cells in culture to ionizing radiation, but the actual inducing agents for this gene modulation response are unknown. In these experiments, it was seted out to identify genes that would be modulated in response to two different concentrations of WR1065 (i. e., a lower dose that is incapable of protecting against cell killing but effective in protecting against mutation induction, and a high dose that is effective in protecting against both end points). Using differential display reverse transcription-PCR, it was compared genes expressed in untreated cells to those expressed in cells treated with different concentrations of WR1065 (4 mм or 40 'мю'м) with or without radiation exposure (7.5 Gy). One band, which showed a differential response, was sequenced and found to have homology in the 3'-untranslated region of the mouse thymidine kinase (tk) gene but not identity to the Chinese hamster ovary tk gene. Dot blot and Northern blot analyses confirmed the dfferential display results and also determined that regulation of the tk-like gene is similar to that of tk itself. These experiments estabilished that in Chinese hamster ovary cells, radiation causes a repression in accumulation of tk mRNA and a related tk-like transcript. This repression is made less dramatic by the presence of 40 'мю'м WR1065, and, in fact, expression becomes enhanced when cells are pretreated with 4 mм WR1065. This suggests a role for regulation of tk and its related gene in the survival response of cells after exposure to ionizing radiation. Библ. 46

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.21.09.13
Рубрики: КУЛЬТУРА КЛЕТОК
CHO
ТИМИДИНКИНАЗА
МРНК
ЭКСПРЕССИЯ
ТРАНСКРИПТЫ
РАДИОПРОТЕКТОР WR1065
IN VITRO

Доп.точки доступа:
Woloschak, Gayle E.; Paunesku, Tatjana; Chang-Liu, Chin-Mei; Grdina, David J.

РЖ ВИНИТИ 34 (BI36) 97.04-04А4.35

Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065 [Text] / Gayle E. Woloschak [et al.] // Cancer Res. - 1995. - Vol. 55, N 21. - P4788-4792 . - ISSN 0008-5472
Перевод заглавия: Экспрессия мРНК тимидинкиназы и связанных транскриптов модулируется радиопротектором WR1065
Аннотация: Previous studies have shown that the radioprotector WR1065 protects against mutagenesis across a wide concentration range (i. e., 40 'мю'м to 4 mм) but protects against cell killing by ionizing radiation at concentrations greater than 1 mм. Other work has demonstrated that many genes are induced or repressed after exposure of cells in culture to ionizing radiation, but the actual inducing agents for this gene modulation response are unknown. In these experiments, it was seted out to identify genes that would be modulated in response to two different concentrations of WR1065 (i. e., a lower dose that is incapable of protecting against cell killing but effective in protecting against mutation induction, and a high dose that is effective in protecting against both end points). Using differential display reverse transcription-PCR, it was compared genes expressed in untreated cells to those expressed in cells treated with different concentrations of WR1065 (4 mм or 40 'мю'м) with or without radiation exposure (7.5 Gy). One band, which showed a differential response, was sequenced and found to have homology in the 3'-untranslated region of the mouse thymidine kinase (tk) gene but not identity to the Chinese hamster ovary tk gene. Dot blot and Northern blot analyses confirmed the dfferential display results and also determined that regulation of the tk-like gene is similar to that of tk itself. These experiments estabilished that in Chinese hamster ovary cells, radiation causes a repression in accumulation of tk mRNA and a related tk-like transcript. This repression is made less dramatic by the presence of 40 'мю'м WR1065, and, in fact, expression becomes enhanced when cells are pretreated with 4 mм WR1065. This suggests a role for regulation of tk and its related gene in the survival response of cells after exposure to ionizing radiation. Библ. 46

ГРНТИ	34.49.19

ВИНИТИ 341.49.19.33
Рубрики: КУЛЬТУРА КЛЕТОК
CHO
ТИМИДИНКИНАЗА
МРНК
ЭКСПРЕССИЯ
ТРАНСКРИПТЫ
РАДИОПРОТЕКТОР WR1065
IN VITRO

Доп.точки доступа:
Woloschak, Gayle E.; Paunesku, Tatjana; Chang-Liu, Chin-Mei; Grdina, David J.

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