СибНСХБ

Вид поиска

Область поиска

Найдено в других БД

Формат представления найденных документов:
библиографическое описание	краткий	полный

Отсортировать найденные документы по:
автору	заглавию	году издания	типу документа

Поисковый запрос: (<.>S=ПРОТИВ АНТИГЕНА GAL<.>)

Общее количество найденных документов : 3
Показаны документы с 1 по 3

РЖ ВИНИТИ 34 (BI39) 95.09-04К1.568

Specific stimulation of Graves' disease thyrocytes by the natural anti-gal antibody from normal and autologous serum [Text] / Roger J. Winand [et al.] // J. Immunol. - 1994. - Vol. 153, N 3. - P1386-1395 . - ISSN 0022-1767
Перевод заглавия: Специфическая стимуляция тироцитов при болезни Грейвса естественными антителами против антигена Gal из нормальной и аутологичной сыворотки
Аннотация: Anti-Gal is a natural Ab abundantly produced in humans. It interacts specifically with the carbohydrate epitope Gal'альфа'1-3Gal'бета'1-4GlcNAc-R (termed the 'альфа'-galactosyl epitope). This epitope is expressed in large amounts on thyrocytes of nonprimate mammals, but not of humans. We have previously found that binding of anti-Gal to 'альфа'-galactosyl epitopes on porcine thyrocytes results in stimulatory effects similar to those exerted by throid-stimulating hormone (thyrotropin). In the present study, we tested the hypothesis that anti-Gal may contribute to Graves' disease (GD) pathogenesis by stimulation of the thyrocytes of patients with this autoimmune disorder. Anti-Gal binding and stimulatory effects were assessed in primary thyrocyte cultures. Anti-Gal specifically bound to GD thyrocytes and induced an increase in cAMP synthesis, {125}I uptake, and DNA synthesis in these cells. Furthermore, the stimulatory effects of autologous sera on GD thyrocytes were greatly reduced after specific depletion of anti-Gal from these sera. No binding and no stimulatory effects of anti-Gal were observed, however, with normal human thyrocytes and with thyrocytes from thyrotoxic patients who lack thyroid-stimulating lgs or thyrotropin binding inhibiting lgs. These in vitro stimulatory effects of anti-Gal on GD thyrocytes suggest that this natural Ab may contribute to the in vivo continuous stimulation of thyrocytes in GD patients. The possibility that anti-Gal may stimulate GD thyrocytes via interaction with aberrantly expressed 'альфа'-galactosyl epitopes on the thyroid-stimulating hormone receptor is discussed. Бельгия, Inst. Pathol., Univ. Liege

ГРНТИ	34.43.55

ВИНИТИ 341.43.55.25.17
Рубрики: АУТОАНТИТЕЛА
ПРОТИВ АНТИГЕНА GAL
СТИМУЛЯЦИЯ ТИРОЦИТОВ
БОЛЕЗНЬ ГРЕЙВСА
ЧЕЛОВЕК

Доп.точки доступа:
Winand, Roger J.; Devigne, Julienne Winand; Meurisse, Michel; Galili, Uri

РЖ ВИНИТИ 34 (BI27) 95.11-04М6.118

Specific stimulation of Graves' disease thyrocytes by the natural anti-gal antibody from normal and autologous serum [Text] / Roger J. Winand [et al.] // J. Immunol. - 1994. - Vol. 153, N 3. - P1386-1395 . - ISSN 0022-1767
Перевод заглавия: Специфическая стимуляция тироцитов при болезни Грейвса естественными антителами против антигена Gal из нормальной и аутологичной сыворотки
Аннотация: Anti-Gal is a natural Ab abundantly produced in humans. It interacts specifically with the carbohydrate epitope Gal'альфа'1-3Gal'бета'1-4GlcNAc-R (termed the 'альфа'-galactosyl epitope). This epitope is expressed in large amounts on thyrocytes of nonprimate mammals, but not of humans. We have previously found that binding of anti-Gal to 'альфа'-galactosyl epitopes on porcine thyrocytes results in stimulatory effects similar to those exerted by throid-stimulating hormone (thyrotropin). In the present study, we tested the hypothesis that anti-Gal may contribute to Graves' disease (GD) pathogenesis by stimulation of the thyrocytes of patients with this autoimmune disorder. Anti-Gal binding and stimulatory effects were assessed in primary thyrocyte cultures. Anti-Gal specifically bound to GD thyrocytes and induced an increase in cAMP synthesis, {125}I uptake, and DNA synthesis in these cells. Furthermore, the stimulatory effects of autologous sera on GD thyrocytes were greatly reduced after specific depletion of anti-Gal from these sera. No binding and no stimulatory effects of anti-Gal were observed, however, with normal human thyrocytes and with thyrocytes from thyrotoxic patients who lack thyroid-stimulating lgs or thyrotropin binding inhibiting lgs. These in vitro stimulatory effects of anti-Gal on GD thyrocytes suggest that this natural Ab may contribute to the in vivo continuous stimulation of thyrocytes in GD patients. The possibility that anti-Gal may stimulate GD thyrocytes via interaction with aberrantly expressed 'альфа'-galactosyl epitopes on the thyroid-stimulating hormone receptor is discussed. Бельгия, Inst. Pathol., Univ. Liege

ГРНТИ	34.39.39

ВИНИТИ 341.39.39.21.37.39
Рубрики: АУТОАНТИТЕЛА
ПРОТИВ АНТИГЕНА GAL
СТИМУЛЯЦИЯ ТИРОЦИТОВ
БОЛЕЗНЬ ГРЕЙВСА
ЧЕЛОВЕК

Доп.точки доступа:
Winand, Roger J.; Devigne, Julienne Winand; Meurisse, Michel; Galili, Uri

РЖ ВИНИТИ 34 (BI39) 97.02-04К1.35

Witort, Ewa.
Detection of anti-Gal xenoantibodies in the sera of 'альфа'-Gal knockout mice [Text] : abstr. Annu. Sci. Meet. Transplant. Soc. Austral. and N.Z., Canberra, 17-19 Apr., 1996 / Ewa Witort, Martin J. Pearse, Anthony J. F. d'Apice // Immunol. and Cell Biol. - 1996. - Vol. 74, N 3. - P23 . - ISSN 0818-9641
Перевод заглавия: Выявление ксеноантител против антигена Gal в сыворотке нокаутированных по 'альфа'-Gal мышей

ГРНТИ	34.43.05

ВИНИТИ 341.43.05.09
Рубрики: КСЕНОГЕННЫЕ АНТИТЕЛА
ПРОТИВ АНТИГЕНА GAL
ВЫЯВЛЕНИЕ
НОКАУТИРОВАННЫЕ ПО GAL АЛЬФА МЫШИ

Доп.точки доступа:
Pearse, Martin J.; d'Apice, Anthony J.F.

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

rtvarBDview(" результаты поиска","20190607010228","4682442");

Вид поиска