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РЖ ВИНИТИ 34 (BI48) 96.06-04Т2.427

Ahmed, S. A.
Effect of schistosomal infection and its treatment on some key enzymes of glucose metabolism in mice livers [Text] / S. A. Ahmed, M. Z. Gad // Arzneim.-Forsch. - 1995. - Vol. 45, N 12. - P1324-1328 . - ISSN 0004-4172
Перевод заглавия: Действие шистосомной инфекции и лечения на некоторые ключевые ферменты метаболизма глюкозы в печени мышей
Аннотация: Three antischistosomal drugs, praziquantel (CAS 55268-74-1, EMBAY 8440, Prz), oxamniquine (CAS 21738-42-1, Oxa) and oltipraz (CAS 64224-21-1, Olt) were examined for their ability to reverse the disturbances in carbohydrate metabolism induced by Schistosoma mansoni (S. mansoni) infection. The infected mice were screened every 2 weeks for 16 weeks for their body and liver weights in addition to assessment of the activities of liver pyruvate kinase (PK), phosphofructokinase (PFK) (glycolysis), citrate synthase (CS) (Krebs' cycle) glycogen phosphorylase (GP) (glycogenolysis), glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) (hexose monophosphate shunt). Results of the study showed that infection with S. mansoni caused the following changes in mice livers: 1. significant increase in liver weights from 6th week of infection, which coincided with schistosomal egg deposition, whereas body weights were reduced, 2. remarkable increase in the activities of PK and PFK from the 4th week of infection, 3. marked reduction in CS, GP, G6PDH and 6PGDH. These results lead to the conclusion that glycolysis is largely stimulated in the livers of infected mice on the expense of other metabolic pathways of glucose utilization. Administration of Prz to infected mice caused normalization of all measured enzyme activities almost from the 2nd week of infection, whereas liver and body weights were improved from the 10th week. Oxa was less effective in these regards while Olt was the least. These data support the selection of Prz as a drug of choice for S. mansoni infection. АРЕ, Depart. of Medicinal Chemistry, National Research Center, Cairo. Библ. 50

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.59
Рубрики: ПРОТИВОГЛИСТНЫЕ СРЕДСТВА
ПРАЗИКВАНТЕЛ
ОКСАМНИХИН
ОЛТИПРАЗ
МЕТАБОЛИЗМ ГЛЮКОЗЫ
КЛЮЧЕВЫЕ ФЕРМЕНТЫ
ПЕЧЕНЬ
ПРОТИВОШИСТОСОМНАЯ АКТИВНОСТЬ
SCHISTOSOMA MANSONI
МЫШИ

Доп.точки доступа:
Gad, M.Z.

РЖ ВИНИТИ 34 (BI48) 96.06-04Т2.428

Lethal effect of oxamnioquine and praziquantel on mice experimentally infected with Schistosoma mansoni [Text] / Sonia Maria A. F. Tonelli [et al.] // Rev. Inst. med. trop. Sao Paulo. - 1995. - Vol. 37, N 4. - P361-363 . - ISSN 0036-4665
Перевод заглавия: Летальное действие оксамнихина и празиквантела у мышей, экспериментально инфицированных Schistosoma mansoni
Аннотация: Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results inicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed. Бразилия, Prof. Paulo Marcos Z. Coelho, Depart. de Parasitologia, ICB/UFMG, Caixa Postal 486, 30.161-970 Belo Horizonte, MG. Библ. 9

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.59
Рубрики: ПРОТИВОГЛИСТНЫЕ СРЕДСТВА
ОКСАМНИХИН
ПРАЗИКВАНТЕЛ
ПРОТИВОШИСТОСОМНАЯ АКТИВНОСТЬ
SCHISTOSOMA MANSONI
ИНФИЦИРОВАННЫЕ МЫШИ
ЛЕТАЛЬНОЕ ДЕЙСТВИЕ

Доп.точки доступа:
Tonelli, Sonia Maria A.F.; Goulart, Eugenio M.A.; Tonelli, Edward; Coelho, Paulo Marcos Zech

РЖ ВИНИТИ 34 (BI50) 96.09-04И2.156

Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni [Text] / Sonia Maria A. F. Tonelli [et al.] // Rev. Inst. med. trop. Sao Paulo. - 1995. - Vol. 37, N 4. - P361-363 . - ISSN 0036-4665
Перевод заглавия: Летальное действие оксамнихина и празиквантела у мышей, экспериментально инфицированных Schistosoma mansoni
Аннотация: Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results inicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed. Бразилия, Prof. Paulo Marcos Z. Coelho, Depart. de Parasitologia, ICB/UFMG, Caixa Postal 486, 30.161-970 Belo Horizonte, MG. Библ. 9

ГРНТИ	34.33.23

ВИНИТИ 341.33.23.17.11.02
Рубрики: ПРОТИВОГЛИСТНЫЕ СРЕДСТВА
ОКСАМНИХИН
ПРАЗИКВАНТЕЛ
ПРОТИВОШИСТОСОМНАЯ АКТИВНОСТЬ
SCHISTOSOMA MANSONI
ИНФИЦИРОВАННЫЕ МЫШИ
ЛЕТАЛЬНОЕ ДЕЙСТВИЕ

Доп.точки доступа:
Tonelli, Sonia Maria A.F.; Goulart, Eugenio M.A.; Tonelli, Edward; Coelho, Paulo Marcos Zech

РЖ ВИНИТИ 34 (BI50) 96.09-04И2.170

Ahmed, S. A.
Effect of schistosomal infection and its treatment on some key enzymes of glucose metabolism in mice livers [Text] / S. A. Ahmed, M. Z. Gad // Arzneim.-Forsch. - 1995. - Vol. 45, N 12. - P1324-1328 . - ISSN 0004-4172
Перевод заглавия: Действие шистосомной инфекции и лечения на некоторые ключевые ферменты метаболизма глюкозы в печени мышей
Аннотация: Three antischistosomal drugs, praziquantel (CAS 55268-74-1, EMBAY 8440, Prz), oxamniquine (CAS 21738-42-1, Oxa) and oltipraz (CAS 64224-21-1, Olt) were examined for their ability to reverse the disturbances in carbohydrate metabolism induced by Schistosoma mansoni (S. mansoni) infection. The infected mice were screened every 2 weeks for 16 weeks for their body and liver weights in addition to assessment of the activities of liver pyruvate kinase (PK), phosphofructokinase (PFK) (glycolysis), citrate synthase (CS) (Krebs' cycle) glycogen phosphorylase (GP) (glycogenolysis), glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) (hexose monophosphate shunt). Results of the study showed that infection with S. mansoni caused the following changes in mice livers: 1. significant increase in liver weights from 6th week of infection, which coincided with schistosomal egg deposition, whereas body weights were reduced, 2. remarkable increase in the activities of PK and PFK from the 4th week of infection, 3. marked reduction in CS, GP, G6PDH and 6PGDH. These results lead to the conclusion that glycolysis is largely stimulated in the livers of infected mice on the expense of other metabolic pathways of glucose utilization. Administration of Prz to infected mice caused normalization of all measured enzyme activities almost from the 2nd week of infection, whereas liver and body weights were improved from the 10th week. Oxa was less effective in these regards while Olt was the least. These data support the selection of Prz as a drug of choice for S. mansoni infection. АРЕ, Depart. of Medicinal Chemistry, National Research Center, Cairo. Библ. 50

ГРНТИ	34.33.23

ВИНИТИ 341.33.23.17.11.19
Рубрики: ПРОТИВОГЛИСТНЫЕ СРЕДСТВА
ПРАЗИКВАНТЕЛ
ОКСАМНИХИН
ОЛТИПРАЗ
МЕТАБОЛИЗМ ГЛЮКОЗЫ
КЛЮЧЕВЫЕ ФЕРМЕНТЫ
ПЕЧЕНЬ
ПРОТИВОШИСТОСОМНАЯ АКТИВНОСТЬ
SCHISTOSOMA MANSONI
МЫШИ

Доп.точки доступа:
Gad, M.Z.

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