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РЖ ВИНИТИ 34 (BI27) 96.03-04М6.227

Juang, Jyuhn-Huarng.
Stabilized islet grafts are more efficient than freshly transplanted islets [Text] / Jyuhn-Huarng Juang, Susan Bonner-Weir // Diabetes. - 1994. - Vol. 43, Suppl. n 1. - P139 . - ISSN 0012-1797
Перевод заглавия: Стабилизированные трансплантаты островков более эффективны, чем островки, трансплантированные в свежеприготовленном виде
Аннотация: Syngeneic transplantation of 200 mouse islets under the kidney capsule usually fails to cure streptozocin diabetes. We hypothesized that this number could succeed if grafting were facilitated with the help of additional islets. Therefore, 200 freshly isolated mouse islets were transplanted under the capsules of both kidneys (total of 400 islets) of diabetic mice. Two weeks after transplantation, the recipients were normoglycemic and one of two grafts was removed. The blood glucose levels increased from 151'+-'9 mg/dl (day 0) to 207'+-'14 (day 3) but then decreased back to 158'+-'11 (day 14). At day 14 after graft removal, the beta cell mass doubled (0.20'+-'0.05 vs. 0.10'+-'0.05 mg, P0.02) in contrast to 30% increase in sham (0.13'+-'0.06 mg). At day 3 after graft removal, the replication rate was significantly higher than that at day 0,5 and 14 (1.02'+-'0.20 vs. 0.31'+-'0.08, 0.26'+-'0.04 and 0.31'+-'0.05%/4h, respectively, P0.02) and also sham (0.28'+-'0.11%/4h, P0.04). Meanwhile, the mean individual beta cell area tended to be larger than that of sham (410 vs. 351 'мю'm{2}). These data indicate that an insufficient number of islets, once well-engrafted, can expand its mass and function to successfully surmount transient hyperglycemia

ГРНТИ	34.39.39

ВИНИТИ 341.39.39.21.61.17
Рубрики: СТРЕПТОЗОТОЦИНОВЫЙ ДИАБЕТ
ЛЕЧЕНИЕ
ОСТРОВКИ ПОЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ
ТРАНСПЛАНТАТЫ
СТАБИЛИЗАЦИЯ
МЫШИ

Доп.точки доступа:
Bonner-Weir, Susan

РЖ ВИНИТИ 34 (BI49) 96.04-04М1.453

Angiogenesis and vascularization of murine pancreatic islet isografts [Text] / Peter Vajkoczy [et al.] // Transplantation. - 1995. - Vol. 60, N 2. - P123-127 . - ISSN 0041-1337
Перевод заглавия: Ангиогенез и васкуляризация изотрансплантатов островков поджелудочной железы у мышей
Аннотация: Although the microvascular endothelium has been identified as the primary target site for the initiation of pancreatic islet graft rejection, little is known of the microvascular and cellular mechanisms involved, partly due to the lack of adequate models. Herein, we present a model for the in vivo assessment of the microcirculation of pancreatic islet grafts in mice. Isolated islets of Langerhans from immunocompetent hairless mice and immunoincompetent athymic nude mice were transplanted syngeneically into a specially designed dorsal skinfold chamber mounted on nondiabetic recipients. The islets' microcirculation was visualized by means of intravital fluorescence microscopy, and microcirculatory parameters were quantitatively analysed over a period of 14 days in the awake animal. Between day 2 and 4 after transplantation 84% (31/37; hairless mice) and 69% (36/52; nude mice) of the islet grafts revealed capillary sprouts and formation of new microvessels. On day 6, these sprouts were found interconnected, and red blood cell movement within the newly formed microvascular network was observed. The process of angiogenesis and revascularization was completed within 10 days after transplantation yielding a glomerulus-like network of capillaries as known for pancreatic islets in situ. Functional capillary density of the islet grafts ranged between 650 and 700 cm{-1} in both hairless and nude mice. Within the islets' microvessels neither accumulation of leukocytes nor leukocyte-endothelial cell interaction was observed, indicating the lack of rejection and inflammation in these syngeneic islet grafts. We propose that this model provides a wide spectrum of promising experimental approaches for the study of microcirculatory and cellular mechanisms in free pancreatic islet transplantation. Германия [M. D. Menger], Inst. fur Klinisch-Experimentelle Chirurgie, Univ. des Saarlandes, Universitatsklinikum Homburg/Saar, D-66421 Homburg/Saar. Библ. 24

ГРНТИ	34.03.35

ВИНИТИ 341.03.35.25
Рубрики: ОСТРОВКИ ПОЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ
ТРАНСПЛАНТАЦИЯ
КРОВЕНОСНЫЕ СОСУДЫ
АНГИОГЕНЕЗ
ВАСКУЛЯРИЗАЦИЯ
МЫШИ

Доп.точки доступа:
Vajkoczy, Peter; Menger, Michael D.; Simpson, Elizabeth; Messmer, Konrad

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