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РЖ ВИНИТИ 76 (BI31) 96.01-04Т3.241

Impact of drug dosage and brand on bioavailability and efficacy of praziquantel [Text] / Aiesha Metwally [et al.] // Pharmacol. Res. - 1995. - Vol. 31, N 1. - P53-59 . - ISSN 1043-6618
Перевод заглавия: Влияние дозы и препарата празиквантела на его биодоступность и эффективность
Аннотация: The efficacy of two brands (brand 1=Biltricide; Bayer AG, Leverkusen, Germany; brand 2=Distocide; EPICO pharmaceuticals, Cairo, Egypt) of praziquantel (PZQ) in full and half doses (40 and 20 mg kg{-1}) monitored as percentage egg reduction and cure rate was investigated in S. mansoni infected school-children. A total of 506 school-children (8-16 years of age) were classified into three groups according to their intensity of infection, heavy [500 eggs per grams (epg)], moderate (100-500 epg) and light (100 epg), after examination of three stool samples (three slides per sample) on three consecutive days. Percentage egg reduction and cure rate were monitored 4 and 10 weeks post-treatment for each dose regimen in the different test groups. Before testing the efficacy of either brand in patients, the pharmacokinetic parameters of the two brands were studied in non-infected normal volunteers. Statistical analysis of the pharmacokinetic parameters of brand 1 'ню's brand 2 (in a dose of 20 or 40 mg kg{-1}) revealed no significant no significant difference in elimination (ke), absorption rate constant (ka), elimination half life (t1/2e), area under the time-concentration curve (Auc), serum maximum concentration (Cp[max]) and time to maximum concentration (T[max]). As regards the efficacy of test drugs, statistical analysis revealed that up to 10 weeks posttreatment the two brands of PZQ in full dose were equally effective in reducing egg count as their half doses except in heavily infected cases treated with brand 2 of PZQ. In this group a significantly higher percentage of egg reduction was recorded in patients receiving 40 mg kg{-1} when compared to those treated with 20 mg kg{-1}. Considering patients cured (passing no viable eggs), higher doses of brand 1 and brand 2 produced in several instances a higher percentage of cures than lower doses. However comparison of brand 1 to brand 2 of PZQ whether in full or half dose did not reveal any statistically significant difference in either the cure rate or percent egg reduction. Библ. 20

ГРНТИ	76.31.29

ВИНИТИ 761.31.29.35.07
Рубрики: ПРАЗИКВАНТЕЛ
ПРЕПАРАТЫ
БИЛТРИЦИД
ДИСТОЦИД
ДОЗИРОВАНИЕ
БИОДОСТУПНОСТЬ
ЭФФЕКТИВНОСТЬ
ИШЕТОСОМОЗ
SCHISTOSOMA MANSONI
БОЛЬНЫЕ ДЕТИ

Доп.точки доступа:
Metwally, Aiesha; Bennett, James; Botros, Sanaa; Ebeid, Fatma; El, Attar Gamal-El Din M.

РЖ ВИНИТИ 34 (BI48) 96.01-04Т2.439

Impact of drug dosage and brand on bioavailability and efficacy of praziquantel [Text] / Aiesha Metwally [et al.] // Pharmacol. Res. - 1995. - Vol. 31, N 1. - P53-59 . - ISSN 1043-6618
Перевод заглавия: Влияние дозы и препарата празиквантела на его биодоступность и эффективность
Аннотация: The efficacy of two brands (brand 1=Biltricide; Bayer AG, Leverkusen, Germany; brand 2=Distocide; EPICO pharmaceuticals, Cairo, Egypt) of praziquantel (PZQ) in full and half doses (40 and 20 mg kg{-1}) monitored as percentage egg reduction and cure rate was investigated in S. mansoni infected school-children. A total of 506 school-children (8-16 years of age) were classified into three groups according to their intensity of infection, heavy [500 eggs per grams (epg)], moderate (100-500 epg) and light (100 epg), after examination of three stool samples (three slides per sample) on three consecutive days. Percentage egg reduction and cure rate were monitored 4 and 10 weeks post-treatment for each dose regimen in the different test groups. Before testing the efficacy of either brand in patients, the pharmacokinetic parameters of the two brands were studied in non-infected normal volunteers. Statistical analysis of the pharmacokinetic parameters of brand 1 'ню's brand 2 (in a dose of 20 or 40 mg kg{-1}) revealed no significant no significant difference in elimination (ke), absorption rate constant (ka), elimination half life (t1/2e), area under the time-concentration curve (Auc), serum maximum concentration (Cp[max]) and time to maximum concentration (T[max]). As regards the efficacy of test drugs, statistical analysis revealed that up to 10 weeks posttreatment the two brands of PZQ in full dose were equally effective in reducing egg count as their half doses except in heavily infected cases treated with brand 2 of PZQ. In this group a significantly higher percentage of egg reduction was recorded in patients receiving 40 mg kg{-1} when compared to those treated with 20 mg kg{-1}. Considering patients cured (passing no viable eggs), higher doses of brand 1 and brand 2 produced in several instances a higher percentage of cures than lower doses. However comparison of brand 1 to brand 2 of PZQ whether in full or half dose did not reveal any statistically significant difference in either the cure rate or percent egg reduction. Библ. 20

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.59
Рубрики: ПРАЗИКВАНТЕЛ
ПРЕПАРАТЫ
БИЛТРИЦИД
ДИСТОЦИД
ДОЗИРОВАНИЕ
БИОДОСТУПНОСТЬ
ЭФФЕКТИВНОСТЬ
ИШЕТОСОМОЗ
SCHISTOSOMA MANSONI
БОЛЬНЫЕ ДЕТИ

Доп.точки доступа:
Metwally, Aiesha; Bennett, James; Botros, Sanaa; Ebeid, Fatma; El, Attar Gamal-El Din M.

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