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РЖ ВИНИТИ 34 (BI48) 95.09-04Т1.313

Welch, Sandra P.
Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists: A common mechanism of action? [Text] / Sandra P. Welch, L.Dale Dunlow // J. Pharmacol. and Exp. Ther. - 1993. - Vol. 267, N 1. - P390-399 . - ISSN 0022-3565
Перевод заглавия: Антиноцицептивная активность интратекально введенных [средств], открывающих калиевые каналы, и опиоидных агонистов: общий механизм действия?
Аннотация: The i.t. administration of the potassium channel openers diazoxide, minoxidil, and lemakalim (BRL38227) produced antinociception as measured in the tail-flick test. Minoxidil and lemakalim (BRL 38227) were full agonists, whereas diazoxide was a partial agonist. The antinociception produced by the potassium channel openers (i.t.) was blocked differentially by opiate antagonists (i.t.). The antinociceptive effects of diazoxide were blocked by nor binaltorphimine, ICI 174,864 and naloxone. Minoxidil- and lemakalim-induced antinociception was blocked by naloxone and ICI 174,864, but not by nor-binaltorphimine. Naloxone (s.c.) shifted the dose-effect curve for minoxidil to the right in a parallel manner. Morphineinduced antinociception was partially blocked by glyburide and apamin, whereas that produced by DPDPE was blocked totally by apamin. U50,488H-induced antinociception was blocked partially by apamin. The potassium channel openers (i.t.) were not cross tolerant to morphine when measured in the tail-flick test. Apamin and glyburide precipitated "withdrawal-like" symptoms in morphine-tolerant mice. The interaction of potassium channel openers and opioids probably does not represent a direct interaction of these two classes of drugs at a similar receptor, but rather may occur via an interaction with a common second messenger system such as calcium. США, Virginia Commonwealth Univ., Box 613, MCV Station, Ricmond, VA 23298-0613. Библ. 63

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.15.57.15.02
Рубрики: ДИАЗОКСИД
МИНОКСИДИЛ
ЛЕМАКАЛИМ
МОРФИН
АНТАГОНИСТЫ ОПИОИДОВ
АНТИНОЦИЦЕПЦИЯ
МЕХАНИЗМЫ ДЕЙСТВИЯ
ВТОРИЧНЫЕ ДЕЙСТВИЯ
ВТОРИЧНЫЕ ПОСРЕДНИКИ
МЫШИ

Доп.точки доступа:
Dunlow, L.Dale

РЖ ВИНИТИ 34 (BI24) 95.11-04М3.164

Welch, Sandra P.
Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists: A common mechanism of action? [Text] / Sandra P. Welch, L.Dale Dunlow // J. Pharmacol. and Exp. Ther. - 1993. - Vol. 267, N 1. - P390-399 . - ISSN 0022-3565
Перевод заглавия: Антиноцицептивная активность интратекально введенных [средств], открывающих калиевые каналы, и опиоидных агонистов: общий механизм действия?
Аннотация: The i.t. administration of the potassium channel openers diazoxide, minoxidil, and lemakalim (BRL38227) produced antinociception as measured in the tail-flick test. Minoxidil and lemakalim (BRL 38227) were full agonists, whereas diazoxide was a partial agonist. The antinociception produced by the potassium channel openers (i.t.) was blocked differentially by opiate antagonists (i.t.). The antinociceptive effects of diazoxide were blocked by nor binaltorphimine, ICI 174,864 and naloxone. Minoxidil- and lemakalim-induced antinociception was blocked by naloxone and ICI 174,864, but not by nor-binaltorphimine. Naloxone (s.c.) shifted the dose-effect curve for minoxidil to the right in a parallel manner. Morphineinduced antinociception was partially blocked by glyburide and apamin, whereas that produced by DPDPE was blocked totally by apamin. U50,488H-induced antinociception was blocked partially by apamin. The potassium channel openers (i.t.) were not cross tolerant to morphine when measured in the tail-flick test. Apamin and glyburide precipitated "withdrawal-like" symptoms in morphine-tolerant mice. The interaction of potassium channel openers and opioids probably does not represent a direct interaction of these two classes of drugs at a similar receptor, but rather may occur via an interaction with a common second messenger system such as calcium. США, Virginia Commonwealth Univ., Box 613, MCV Station, Ricmond, VA 23298-0613. Библ. 63

ГРНТИ	34.39.15

ВИНИТИ 341.39.15.29
Рубрики: ДИАЗОКСИД
МИНОКСИДИЛ
ЛЕМАКАЛИМ
МОРФИН
АНТАГОНИСТЫ ОПИОИДОВ
АНТИНОЦИЦЕПЦИЯ
МЕХАНИЗМЫ ДЕЙСТВИЯ
ВТОРИЧНЫЕ ДЕЙСТВИЯ
ВТОРИЧНЫЕ ПОСРЕДНИКИ
МЫШИ

Доп.точки доступа:
Dunlow, L.Dale

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