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РЖ ВИНИТИ 76 (BI28) 97.07-04Н3.255

Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity [Text] / Shiv R. Khandelwal [et al.] // Radiat. Oncol. Investigat. - 1996. - Vol. 4, N 2. - P51-59 . - ISSN 1065-7541
Перевод заглавия: Увеличенный ответ на облучение фибросаркомы FSaII у мышей С3Н, обусловленный введением аллостерического эффектора аффинности гемоглобина-кислорода
Аннотация: RSR13, 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpro- pionic acid, stabilizes deoxyhemoglobin and increases O[2] delivery to normal muscle in C3H mice. The effect of RSR13 on the hypoxic fraction of FSaII fibrosarcoma isotransplants in C3H mice was determined by measuring FSaII cell survival following radiation exposures. RSR13 (300 mg/kg) was administered i. p. 20 min prior to irradiation. In tumor growth delay experiments (n=90), FSaII tumor growth was reduced by the combination of RSR13 and radiation relative to radiation alone (P=0.01 for a single exposure and P=0.06 for multiple exposures). RSR13 alone did not affect tumor growth. In clonogenic assay experiments (n=196), tumors in mice were exposed to RSR13 and either air or carbogen (95% O[2], 5% CO[2]) breathing during single radiation exposures of up to 15 Gy, and FSaII cell survival was determined in vitro. FSaII cell survival was significantly (P0.0001) reduced in mice that were exposed to RSR13 and carbogen compared to mice exposed to RSR13 and air, carbogen only, or air only. RSR13 and radiation dose responses were also tested in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay, and 1 hr exposures of RSR13 (concentrations up to 3 mM)'+-'3 Gy or 4.5 Gy did not affect FSaII cell proliferation. RSR13 probably increases O[2] delivery to and reduces the hypoxic fraction of FSaII tumors. Библ. 37

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.55.13.05
Рубрики: ОПУХОЛИ ЭКСПЕРИМЕНТАЛЬНЫЕ
ФИБРОСАРКОМА FSAII
РАДИОСЕНСИБИЛИЗАТОРЫ
RSR13
АФФИННОСТЬ ГЕМОГЛОБИН-КИСЛОРОД
МЫШИ

Доп.точки доступа:
Khandelwal, Shiv R.; Lin, Peck-Sun; Hall, Clarence E.; Truong, Quynhmai T.; Lu, Jiandong; Laurent, Jeffrey J.; Joshi, Gajanan S.; Abraham, Donald J.; Schmidt-Ulrich, Rupert K.

РЖ ВИНИТИ 34 (BI36) 97.09-04А4.325

Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity [Text] / Shiv R. Khandelwal [et al.] // Radiat. Oncol. Investigat. - 1996. - Vol. 4, N 2. - P51-59 . - ISSN 1065-7541
Перевод заглавия: Увеличенный ответ на облучение фибросаркомы FSaII у мышей С3Н, обусловленный введением аллостерического эффектора аффинности гемоглобина-кислорода
Аннотация: RSR13, 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpro- pionic acid, stabilizes deoxyhemoglobin and increases O[2] delivery to normal muscle in C3H mice. The effect of RSR13 on the hypoxic fraction of FSaII fibrosarcoma isotransplants in C3H mice was determined by measuring FSaII cell survival following radiation exposures. RSR13 (300 mg/kg) was administered i. p. 20 min prior to irradiation. In tumor growth delay experiments (n=90), FSaII tumor growth was reduced by the combination of RSR13 and radiation relative to radiation alone (P=0.01 for a single exposure and P=0.06 for multiple exposures). RSR13 alone did not affect tumor growth. In clonogenic assay experiments (n=196), tumors in mice were exposed to RSR13 and either air or carbogen (95% O[2], 5% CO[2]) breathing during single radiation exposures of up to 15 Gy, and FSaII cell survival was determined in vitro. FSaII cell survival was significantly (P0.0001) reduced in mice that were exposed to RSR13 and carbogen compared to mice exposed to RSR13 and air, carbogen only, or air only. RSR13 and radiation dose responses were also tested in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay, and 1 hr exposures of RSR13 (concentrations up to 3 mM)'+-'3 Gy or 4.5 Gy did not affect FSaII cell proliferation. RSR13 probably increases O[2] delivery to and reduces the hypoxic fraction of FSaII tumors. Библ. 37

ГРНТИ	34.49.47

ВИНИТИ 341.49.47.11.13.15
Рубрики: ОПУХОЛИ ЭКСПЕРИМЕНТАЛЬНЫЕ
ФИБРОСАРКОМА FSAII
РАДИОСЕНСИБИЛИЗАТОРЫ
RSR13
АФФИННОСТЬ ГЕМОГЛОБИН-КИСЛОРОД
МЫШИ

Доп.точки доступа:
Khandelwal, Shiv R.; Lin, Peck-Sun; Hall, Clarence E.; Truong, Quynhmai T.; Lu, Jiandong; Laurent, Jeffrey J.; Joshi, Gajanan S.; Abraham, Donald J.; Schmidt-Ulrich, Rupert K.

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