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РЖ ВИНИТИ 34 (BI39) 96.01-04К1.181

DeKoning, Jenefer.
Contrast between class I and class II MHC-mediated differentiation of a CD4{+}CD8{+} T cell line: Implications for lineage commitment [Text] / Jenefer DeKoning, Francis R. Carbone, Jonathan Kaye // Int. Immunol. - 1995. - Vol. 7, N 4. - P541-549 . - ISSN 0953-8178
Перевод заглавия: Различия между определяемой классами I и классами II ГКГС дифференцировкой CD4{+}CD8{+} Т-клеточных линий. Значение линейных свойств
Аннотация: Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4{+} helper or CD8{+} cytotoxic T cell lineages is ultimately dependent upon the specificity of the TCR for class II or class I MHC molecules respectively. However, the initial mechanistic events involved in this process remain unclear. To address this issue, we have expressed a TCR specific for an ovalbumin peptide and the K{b} class I MHC molecule in the DPK CD4{+}CD8{-} precursor T cell line. This cell line originally expressed a TCR specific for a pigeon cytochrome c peptide and class II MHC molecules and has been shown previously to differentiate into CD4{+}CD8{-} cells upon recognition of antigen in vitro or thymic epithelial cells in vivo. Surprisingly, we find that recognition of either class I or class II MHC by these cells initiates differentiation into the CD4{+} lineage and induces down-regulation of recombination associated genes. Unlike recognition of class II MHC, however, recognition of class I MHC does not induce full maturation. These results support a model in which (i) commitment to the CD4 lineage occurs prior to positive selection and (ii) CD4 lineage commitment is associated with a requirement for activation by a class II MHC-specific TCR in order to complete differentiation. США, Dep. Immunol., Scripps Res. Inst., La Jolla, CA92037. Библ. 41

ГРНТИ	34.43.35

ВИНИТИ 341.43.35.05.13
Рубрики: ГКГС
АНТИГЕНЫ КЛАССА I И II
РЕГУЛИРУЮЩАЯ РОЛЬ
ЛИМФОЦИТЫ Т
ДИФФЕРЕНЦИРОВКА
МЫШИ

Доп.точки доступа:
Carbone, Francis R.; Kaye, Jonathan

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