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РЖ ВИНИТИ 34 (BI48) 95.11-04Т1.477

Lau, Chyan E.
Oral and IP caffeine pharmacokinetics under a chronic food-limitation condition [Text] / Chyan E. Lau, Fang Ma, John L. Falk // Pharmacol., Biochem. and Behav. - 1995. - Vol. 50, N 2. - P245-252 . - ISSN 0091-3057
Перевод заглавия: Фармакокинетика кофеина при пероральном и внутрибрюшинном [введении] в условиях хронического ограничения [потребления] пищи
Аннотация: For food-limited rats, serum caffeine was proportional to IP caffeine doses (10-40 mg/kg) for C[max] and area under the curve [AUC[(0-24 h)]], whereas the three dimethylxanthine (DMX) metabolites of caffeine were disproportional over the dose range. Steady-state concentrations of caffeine and the three metabolites were evident at the 11th day of chronic, daily caffeine IP 20 mg/kg doses. Both caffeine and the three metabolites were dose proportional for C[max] and AUC[(0-24 h)] by schedule-induced oral caffeine self-administration within the dose range taken (9-38 mg/kg). These results contrast with the nonlinear kinetics of caffeine reported for rats under ad lib conditions. Elimination rate constants (K[el]) remained the same for the two routes, but apparent volume of distribution (A V[d]) and clearance (Cl) were different. The order of the K[el] values was caffeine paraxanthine theophylline theobromine. The effects of linear vs, nonlinear caffeine pharmacokinetics may have distinct implications for the resulting pharmacodynamics. США, Rutgers Univ. New Brunswick, NJ 08903. Библ. 40

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.15.39
Рубрики: КОФЕИН
ПЕРОРАЛЬНОЕ ВВЕДЕНИЕ
ВНУТРИБРЮШИННОЕ ВВЕДЕНИЕ
ФАРМАКОКИНЕТИКА
ХРОНИЧЕСКОЕ ОГРАНИЧЕНИЕ ПОТРЕБЛЕНИЯ ПИЩИ
КРЫСЫ

Доп.точки доступа:
Ma, Fang; Falk, John L.

РЖ ВИНИТИ 34 (BI35) 95.11-04Т5.102

Lau, Chyan E.
Oral and IP caffeine pharmacokinetics under a chronic food-limitation condition [Text] / Chyan E. Lau, Fang Ma, John L. Falk // Pharmacol., Biochem. and Behav. - 1995. - Vol. 50, N 2. - P245-252 . - ISSN 0091-3057
Перевод заглавия: Фармакокинетика кофеина при пероральном и внутрибрюшинном [введении] в условиях хронического ограничения [потребления] пищи
Аннотация: For food-limited rats, serum caffeine was proportional to IP caffeine doses (10-40 mg/kg) for C[max] and area under the curve [AUC[(0-24 h)]], whereas the three dimethylxanthine (DMX) metabolites of caffeine were disproportional over the dose range. Steady-state concentrations of caffeine and the three metabolites were evident at the 11th day of chronic, daily caffeine IP 20 mg/kg doses. Both caffeine and the three metabolites were dose proportional for C[max] and AUC[(0-24 h)] by schedule-induced oral caffeine self-administration within the dose range taken (9-38 mg/kg). These results contrast with the nonlinear kinetics of caffeine reported for rats under ad lib conditions. Elimination rate constants (K[el]) remained the same for the two routes, but apparent volume of distribution (A V[d]) and clearance (Cl) were different. The order of the K[el] values was caffeine paraxanthine theophylline theobromine. The effects of linear vs, nonlinear caffeine pharmacokinetics may have distinct implications for the resulting pharmacodynamics. США, Rutgers Univ. New Brunswick, NJ 08903. Библ. 40

ГРНТИ	34.47.67

ВИНИТИ 341.47.67.11.19
Рубрики: КОФЕИН
ПЕРОРАЛЬНОЕ ВВЕДЕНИЕ
ВНУТРИБРЮШИННОЕ ВВЕДЕНИЕ
ФАРМАКОКИНЕТИКА
ХРОНИЧЕСКОЕ ОГРАНИЧЕНИЕ ПОТРЕБЛЕНИЯ ПИЩИ
КРЫСЫ

Доп.точки доступа:
Ma, Fang; Falk, John L.

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