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РЖ ВИНИТИ 34 (BI39) 95.12-04К1.321

Regulation of the p70{zap} tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase [Text] / Tomas Mustelin [et al.] // Eur. J. Immunol. - 1995. - Vol. 25, N 4. - P942-946 . - ISSN 0014-2980
Перевод заглавия: Регуляция p70{zap} тирозинпротеинкиназы в Т-клетках фосфотирозинфосфатазой CD45
Аннотация: Two classes of protein tyrosine kinases (PTK) are utilized by the T cell antigen receptor (TcR)/CD3 complex for initiation of the signaling cascade, the Src-family PTK p56{lck} and p59{fyn}, and the Syk-family PTK p70{zap} and p72{syk}. In addition, the CD45 phosphotyrosine phosphatase (PTPase) is required for the induction of tyrosine phosphorylation by the TcR/CD3, presumably by positively regulating Src-family PTK. Here we report that CD45 also regulates the Syk-family PTK p70{zap} (or ZAP-70). In CD45-negative T cells, p70{zap} was constitutively phosphorylated on tyrosine and co-immunoprecipitated with the TcR-'дзета' chain. In resting wild-type CD45-positive cells, p70{zap} was mainly unphosphorylated, but it was rapidly phosphorylated on tyrosine upon treatment of the cells with anti-CD3 or PTPase inhibitors. Finally, p70{zap} co-disctributed with CD45 in intact T cells, and tyrosine phosphorylated p70{zap} was dephosphorylated by CD45 in vitro. These findings suggest that CD45 plays an important role, direct or indirect, in the regulation of p70{zap} and its function in TcR/CD3 signaling. США, Inst. Allergy and Immunol., La Jolla, CA 92037. Библ. 43

ГРНТИ	34.43.35

ВИНИТИ 341.43.35.15.05
Рубрики: ЛИМФОЦИТЫ T
БЕЛОК P70{ZAP}
ТИРОЗИНПРОТЕИНКИНАЗА
ФОСФОТИРОЗИНФОСФОТАЗА CD45
СИГНАЛЬНАЯ СИСТЕМА

Доп.точки доступа:
Mustelin, Tomas; Williams, Scott; Tailor, Pankaj; Couture, Clement; Zenner, Georg; Burn, Paul; Ashwell, Jonathan D.; Altman, Amnon

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