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РЖ ВИНИТИ 34 (BI39) 95.08-04К1.301

Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor [Text] / Toshio Kukita [et al.] // J. Immunol. - 1994. - Vol. 153, N 11. - P5265-5273 . - ISSN 0022-1767
Перевод заглавия: Новый поверхностноклеточный антиген, экспрессируемый на остеокластах мыши, регулирующий функцию рецептора для кальцитонина
Аннотация: Osteoclasts are known to be hematopoietic in origin. However, the detailed mechanisms of their differentiation and activation are not known. Cell-surface molecules preferentially expressed on cells of the osteoclast lineage may play some important roles in these processes. We prepared a mAb that recognizes a unique cell-surface membrane protein specifically expressed on rat osteoclasts. Expression of this Ag, designated as Kat1 Ag, was markedly stimulated by a factor secreted by the osteoblastic cell line ROS 17/2.8. Binding studies of {125}I-labeled calcitonin (CT) showed that the Ag was not the CT receptor (CTR). However, interestingly, studies of the biologic activity of this mAb that recognizes Kat1-antigen (mAb Kat1) revealed possible regulatory functions of this Ag in osteoclasts. Firstly, mAb Kat1 significantly elevated the binding affinity of the CTR expressed on osteoclast-like cells without altering the number of receptors. Secondly, CT-sensitivity of the osteoclast progenitor cells in the system of osteoclast differentiation showed marked augmentation on treatment of these cells with this mAb. Even a very low concentration of CT (0.1 ng/ml) significantly inhibited osteoclast differentiation in the presence of mAb Kat1, whereas a higher concentration of CT (10 ng/ml) was required to inhibit their differentiation in the absence of this mAb. Thirdly, mAb Kat1 inhibited dentin-resorbing activity of osteoclast-like cells. Furthermore, the inhibitory effects of CT on osteoclast-mediated dentin resorption was augmented by the presence of this mAb. These observations strongly suggest that Kat1-antigen is a unique cell-surface protein regulating the affinity of the CTR expressed on osteoclasts and also the bone-resorbing function of these cells

ГРНТИ	34.43.29

ВИНИТИ 341.43.29.31
Рубрики: ПОВЕРХНОСТНЫЕ МАРКЕРЫ
ОСТЕОКЛАСТЫ
РЕЦЕПТОР ДЛЯ КАЛЬЦИТОНИНА
РЕГУЛЯЦИЯ ФУНКЦИИ
МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА

Доп.точки доступа:
Kukita, Toshio; Kukita, Akiko; Nagata, Kengo; Maeda, Hidefumi; Kurisu, Kojiro; Watanabe, Takeshi; Iijima, Tadahiko

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