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РЖ ВИНИТИ 34 (BI24) 96.11-04М3.98

Identification of a 140 kDa protein of rat presynaptic terminal membranes encompassing the active zones [Text] / Anna Stieber [et al.] // Brain Res. - 1995. - Vol. 700, N 1-2. - P261-270 . - ISSN 0006-8993
Перевод заглавия: Идентификация белка мембран пресинаптических окончаний [с молекулярной массой] 140 кДа, окружающих активные зоны
Аннотация: A polyclonal antiserum raised against the carboxy-terminal 17 amino acids of the rat p185{c-neu} (anct) reacted with a 140 kDa polypeptide in membranes of synaptosome fractions from neocortex and hippocampus of 11-day-old and adult rats. The same antiserum reacted with a 185 kDa polypeptide in microsome membranes from rat pheochromocytoma cells (PC12). By light microscopic immunocytochemistry, the anct antibodies against the 140 kDa protein were localized in the neuropile of brain, cerebellum and spinal cord of 11-day-old and adult rats. Especially prominent staining was obtained in the CA2-CA3 zones of the hippocampus, and in the substantia gelatinosa in the spinal cord. The finely granular and diffuse pattern of the immunostain was consistent with synaptic localizations. Interestingly, antibodies against the entire endodomain of p185{c-neu} (a-Bacneu) were localized in granular structures, probably representing axo-somatic and axo-dendritic synapses, on a subset of pyramidal neurons of the CA3 zone. By immunoelectron microscopy, conducted in the hippocampus of adult rats, the anct antibodies were localized at the cytoplasmic site of presynaptic terminals in the giant mossy fiber type in the CA3 and CA4 regions. The immunolocalization of the anct antibodies was restricted in segments of the presynaptic membrane facing the synaptic cleft which include the active zone. The identity and function of the 140 kDa membrane protein of rat brain presynaptic terminals, detected by the anct antibodies, is unknown. Библ. 55

ГРНТИ	34.39.15

ВИНИТИ 341.39.15.25.02
Рубрики: СИНАПСЫ
ПРЕСИНАПТИЧЕСКИЕ ОКОНЧАНИЯ
АКТИВНЫЕ ЗОНЫ
ПОЛИПЕПТИД 140 КДА
ИДЕНТИФИКАЦИЯ
КРЫСЫ

Доп.точки доступа:
Stieber, Anna; Chen, Youjun; Gonatas, Jacqueline; Dougall, William; Qian, Xiaolan; O'Rourke, Donald; Samanta, Arabinda; Greene, Mark I.; Gonatas, Nicholas K.

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