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РЖ ВИНИТИ 34 (BI39) 96.11-04К1.89

Soldevila, Gloria.
Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen [Text] / Gloria Soldevila, Terrence Geiger, Richard A. Flavell // J. Immunol. - 1995. - Vol. 155, N 12. - P5590-5600 . - ISSN 0022-1767
Перевод заглавия: Разрушение иммунологического игнорирования антигенного пептида крупного Т антигена вируса обезьян 40
Аннотация: Expression of the whole SV40 large T Ag (SV40-T) induces transformation of T antigen-expressing cells in vivo, and this phenomenon has been postulated to be the triggering event that leads to autoimmunity in some transgenic mouse models. Here present a model in which a nononcogenic, yet antigenic, fragment of the SV40-T (SV40-Tfrag) is expressed specifically in pancreatic islet 'бета'-cells. In contrast to whole SV40-T transgenic mice, SV40-Tfrag mice that are also transgenic for a TCR specific for the SV40-T are ignorant of Ag in vivo. They do not respond in vivo to the tissue-specific SV40-Tfrag Ag even after priming, but are fully responsive in vitro. This immunologic ignorance cannot be broken after activated SV40-T reactive T cells are transferred into sublethally irradiated mice expressing the isletspecific SV40-Tfrag. However, similar adoptive transfer experiments in mice co-expressing B7-1 and SV40-Tfrag on islet cells specifically lead to Ag recognition and diabetes. This demonstrates that in some circumstances the presence of reactive T cells is not sufficient to break tolerance; rather, costimulation is additionally required to elicit an autoimmune response. This also suggests that SV40-T-induced cellular transformation is important for the autoimmune response directed against SV40-T in other tissue-specific transgenic models. США, Howard Hughes Med. Inst., Yale Univ. Med. Sch., New Haven, CT 06510. Библ. 42

ГРНТИ	34.43.27

ВИНИТИ 341.43.27.15
Рубрики: АНТИГЕН SV40
ОТСУТСТВИЕ ОТВЕТА IN VIVO
РАЗВИТИЕ ОТВЕТА IN VITRO
АУТОИММУННЫЙ ДИАБЕТ
ТРАНСГЕННЫЕ МЫШИ

Доп.точки доступа:
Geiger, Terrence; Flavell, Richard A.

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