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РЖ ВИНИТИ 34 (BI39) 96.03-04К1.538

Nakano, Yumiko.
Nonspecific regulatory mechanism of contact sensitivity: Nonspecific suppressor factor suppresses the antigen-presenting activity of dendritic cells to induce contact sensitivity [Text] / Yumiko Nakano, Shinjiro Hori, Makoto Ihara // Cell. Immunol. - 1994. - Vol. 158, N 1. - P228-240 . - ISSN 0008-8749
Перевод заглавия: Неспецифический регуляторный механизм контактной чувствительности. Неспецифический супрессорный фактор подавляет антиген-представляющую активность дендритных клеток при индукции контактной чувствительности
Аннотация: Nonspecific suppressor factor (NSF), which inhibits the passive transfer of contact sensitivity (CS), is produced from macrophage-like cells induced by oxazolone-conjugated spleen cells. NSF binds selectively to Ia-positive, cyclophosphamide-sensitive, and plastic-adherent non-T cells (named intermediate cells) present in the spleen. NSF-treated intermediate cells acquire the ability to suppress the passive transfer of CS nonspecifically. Because the phenotype of the intermediate cells is similar to that of antigen-presenting cells (APC) of macrophage lineage, we examined the effect of NSF on APC. NSF suppressed the APC activity of draining lymph node cells from mice senditized with fluorescein isothiocyanate or picryl chloride (FITC-LNC or TNP-LNC) to induce CS. Suppressor molecules which suppress the passive transfer of CS and the APC activity were recovered in same fraction around 43 rDa by dye-affinity and gel chromatography purification. The results that the suppressor activity of NSF was absorbed with lymph node cells of FITC-LNC, but not 33D1 or anti-Ia monoclonal antibody plus complement-treated FITC-LNC indicated that NSF reacts directly with antigen-bearing dendritic cells in the draining lymph node. In contrast with spleen cells, lymph node cells did not have the intermediate function, i.e., NSF-treated LNC could not suppress the passive transfer of CS nor the ability of FITC-LNC to induce CS (APC activity). NSF still blocks the ability of FITC-LNC to indece CS after treatment with cyclophosphamide. Thus, the lymph node and spleen include distinct functional cell populations which express la antigen and interact with NSF. APC in the draining lymph node are downregulated directly by NSF and intermediate cells in the spleen play a modulatory role in the suppressor pathway of NSF. Япония, Prefect. Inst. Public Health, Osaka. Библ. 30

ГРНТИ	34.43.51

ВИНИТИ 341.43.51.09.11
Рубрики: ГИПЕРЧУВСТВИТЕЛЬНОСТЬ ЗАМЕДЛЕННОГО ТИПА
АДОПТИВНЫЙ ПЕРЕНОС
НЕСПЕЦИФИЧЕСКИЙ СУПРЕССОРНЫЙ ФАКТОР
ХАРАКТЕРИСТИКА
МЕХАНИЗМ ДЕЙСТВИЯ
ДЕНДРИТНЫЕ КЛЕТКИ
МЫШИ

Доп.точки доступа:
Hori, Shinjiro; Ihara, Makoto

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