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РЖ ВИНИТИ 34 (BI39) 95.12-04К1.74

Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: Identification with the mouse tum{-} transplantation antigen P35B [Text] / Laura Camardella [et al.] // Blood. - 1995. - Vol. 85, N 1. - P264-267 . - ISSN 0006-4971
Перевод заглавия: Первичная структура никотинамид-аденин-динуклеотид фосфата (NADP[H])-связывающего белка FX на эритроцитах человека. Выявление с помощью трансплантационного антигена P35B мышей Tum
Аннотация: Human erythrocytes contain a nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein, FX, whose levels are significantly increased in erythrocytes from glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals bearing the mediterranean variant of G6PD. Elucidation of the still unknown biologic functions of FX was approached by means of amino acid sequencing of its 25 tryptic peptides. Searching in the EMBL data bank allowed identification of extensive homology between these tryptic peptides and all sequence-aligned regions encompassing the complete structure of a putative protein encoded by the P35B gene in the mouse. This gene, which differs from the normal allele by a point mutation, has been previously cloned from a tum{-} variant of the murine tumor cells line P815, so defined because it is associated with low tumorigenicity compared with the progenitor P815. The reported P35B cDNA contains an open reading frame (ORF) of 813 bp and encodes a putative protein of 271 amino acids (30 kD), whereas FX protein is 320 amino acids in length (35.81 kD, in good agreement with previous studies). However, a single base shift at position 4,752 of the P35B gene suppresses the stop codon after Phe 271 and allows continuation of the ORF for up to 320 amino acids to reach the same length as FX. The remarkably high extent (92%) of homology indicates that erythrocyte FX protein is the human homolog of the P35B gene product. Италия, Inst. Protein Biochem. and Enzymol., Naples. Библ. 15

ГРНТИ	34.43.27

ВИНИТИ 341.43.27.15
Рубрики: АНТИГЕНЫ ЭРИТРОЦИТОВ
БЕЛОК, СВЯЗЫВАЮЩИЙ NADF[H]
ПЕРВИЧНАЯ СТРУКТУРА
МЕТОД ВЫЯВЛЕНИЯ
МЫШИНЫЙ БЕЛОК P35B
ЧЕЛОВЕК
МЫШИ

Доп.точки доступа:
Camardella, Laura; Carratore, Vito; Ciardiello, M.Antonietta; Damonte, Gianluca; Benatti, Umberto; De, Flora Antonio

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