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РЖ ВИНИТИ 34 (BI14) 96.06-04Б4.241

Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans [Text] / Gary B. Huffnagle [et al.] // J. Immunol. - 1995. - Vol. 155, N 7. - P3507-3516 . - ISSN 0022-1767
Перевод заглавия: Нижний [уровень] регуляции афферентной фазы легочного воспаления, обусловленного Т-клетками и иммунитет, [обусловленный] меланинпродуцирующим штаммом Cryptocococcus neoformans
Аннотация: The interaction(s) between cryptococcal virulence factors and leukocytes involved in generating protective cell-mediated immunity is not well defined. Intratracheal inoculation of Cryptococcus neoformans strain 52 induced a vigorous T cell-mediated pulmonary inflammatory response that controlled the growth of the organism. In contrast, strain 145 induced a pulmonary inflammatory response that was delayed in onset, slower to develop, and ineffective in controlling the infection. In addition, the expansion of cryptococcus-specific lymphocytes in the pulmonary lymph nodes and titer of specific Abs in the serum of strain 145-infected mice were both diminished markedly. Of the known cryptococcal virulence factors, these two strains differed only in melanin production (52-low and 145-high). Heat-killed strain 145 cryptococci (HKC-145) that had been rendered melanin-negative induced TNF-'альфа' production by alveolar macrophages in vitro and stimulated vigorous cryptococcus-specific lymphoproliferation. In contrast, high melanin-containing HKC-145 inhibited TNF-'альфа' production and lymphoproliferation. In vivo, mice infected with melanin low strain 52, but not melanin high strain 145, had elevated levels of TNF-'альфа' in the bronchoalveolar lavage fluid. Mice co-infected with strains 145 and 52 generated a pulmonary inflammatory response resulting in increased long-term survival. Taken together, these studies demonstrate that melanin does not protect cryptococci from being eliminated in vivo by recruited, activated effector cells; but melanin can inhibit the recognition of the organism by host defenses, thereby downregulating the afferent phase of T cell-mediated immunity, e. g., TNF-'альфа' production and lymphoproliferation. The Journal of Immunology, 1995, 155: 3507-3516. Ил. 7. Табл. 2. Библ. 56

ГРНТИ	34.27.29

ВИНИТИ 341.27.29.21.09
Рубрики: CRYPTOCOCCUS NEOFORMANS (FUNGI)
МЕЛАНИНПРОДУЦИРУЮЩИЕ ШТАММЫ
ИММУНИТЕТ
Т-КЛЕТКИ
ЛЕГОЧНОЕ ВОСПАЛЕНИЕ
ФАЗЫ
РЕГУЛЯЦИЯ

Доп.точки доступа:
Huffnagle, Gary B.; Chen, Gwo-Hsiao; Curtis, Jeffrey L.; McDonald, Roderick A.; Strieter, Robert M.; Toews, Galen B.

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