СибНСХБ

Вид поиска

Область поиска

Найдено в других БД

Формат представления найденных документов:
библиографическое описание	краткий	полный

Поисковый запрос: (<.>S=ЛИМФОЦИТЫ В ПЕРИТОНЕАЛЬНЫЕ<.>)

Общее количество найденных документов : 1

РЖ ВИНИТИ 34 (BI39) 96.03-04К1.321

Hardin, Janet A.
The role of peritoneal stromal cells inthe survival of slgM{+} peritoneal B lymphocyte populations [Text] / Janet A. Hardin, Koichi Yamaguchi, David H. Sherr // Cell. Immunol. - 1995. - Vol. 161, N 1. - P50-60 . - ISSN 0008-8749
Перевод заглавия: Роль перитонеальных стромальных клеток в выживании sIgM{+} популяций перитонеальных B лимфоцитов
Аннотация: Peritoneal (PE) B cells, a large fraction of which belong to the B-1 subset (i.e., the CD5{+} B cell lineage), exhibit unusual growth and/or survival characteristics. To evaluate if these characteristics reflect intrinsic properties of PE B cells or the support provided by a potentially unique peritoneal microenvironment, B cells from various organs were cultured on PE stromal cell monolayers. It was determined that sIgM{+} PE B cell populations survive for notably long periods of time (at least 4 weeks) when cultured with PE stromal. cells. Contact of PE B cells with stromal cell monolayers optimized B cell survival. Although expressing a similar spectrum of adhesion molecules as peritoneal stromal cells, splenic and bone marrow stromal cells were significantly inferior at supporting PE B cells. Increased survival of PE B cells was characterized by a significant but transient increase in proliferation and by an increase in the percentage of B220/CD45{high}/CD5{+} PE B cells. PE stromalcell support of B cell populations did not extend to all B or even to all B-1 cell populations since survival of splenic B cells, only a minority of which belong to the B-1 lineage, or thymic B cells, a majority of which belong to the B-1 lineage, was not enhanced by culture on PE stromal cells. Results demonstrate: (a) a system for relatively long-term maintenance of mature B cells, (b) that the growth/survival of PE B cells is preferentially supported by PE stromal cells, and (c) that growth on PE stromal cells is a characteristic of peritoneal B cells but not necessarily of splenic B cells or B-1 cells from other organs. The suggestion that the local microenvironment contributes to unusual growth, survival, or anatomic distribution of B-1 cells is discussed. США, Dep. Environment. Health, Univ. Med. Sch., Boston, MA02118. Библ. 48

ГРНТИ	34.43.35

ВИНИТИ 341.43.35.15.11
Рубрики: ЛИМФОЦИТЫ В ПЕРИТОНЕАЛЬНЫЕ
ВЫЖИВАНИЕ
СТРОМАЛЬНЫЕ КЛЕТКИ
МЫШИ

Доп.точки доступа:
Yamaguchi, Koichi; Sherr, David H.

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

rtvarBDview(" результаты поиска","20190607010228","4682442");

Вид поиска