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РЖ ВИНИТИ 34 (BI48) 95.10-04Т1.250

Angelis, Luisa de.
Ascorbic acid and atypical antipsychotic drugs: Modulation of aminieptine-induced behavior in mice [Text] / Luisa de Angelis // Brain Res. - 1995. - Vol. 670, N 2. - P303-307 . - ISSN 0006-8993
Перевод заглавия: Аскорбиновая кислота и атипичные антипсихотические средства: модуляция вызываемого аминептином поведения у мышей
Аннотация: To provide a detailed characterization of individual kinds of behavior produced by ascorbic acid in combination with typical (haloperidol) or atypical (clozapine, sulpiride and remoxipride) antipsychotic drugs, the 'open-field' test was selected. Amineptine, an indirect dopamine agonist, was used as an explicit model of dopaminergic activity. Results showed that amineptine (5-10-20 mg/kg i.p.), dose-dependently, increased ambulation and rearing. Ascorbic acid (62.5-125-250 mg/kg i.p.) markedly inhibited the behavior of mice as well as the amineptine-induced hyperactivity. A combination of each typical or atypical antipsychotic drug (except clozapine 2.5 mg/kg i.p.) with amineptine (20 mg/kg i.p.) induced a significant increase in ambulation and rearing over that seen with the antipsychotic drugs alone. The combination of antipsychotic drugs with ascorbic acid 250 mg/kg i.p. led to a decrease in open-field parameters when compared with controls. In conclusion, these data provide further in vivo support for the effect of ascorbic acid on dopaminergic system and demonstrate that the antidopaminergic effects of both typical and atypical antipsychotic drugs may be enhanced with concurrent administration of ascorbic acid. Италия, Univ. of Trieste, 34127 Trieste. Библ. 33

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.15.15 + 341.45.21.23.21
Рубрики: НЕЙРОЛЕПТИКИ
ТИПИЧНЫЕ
АТИПИЧНЫЕ
КИСЛОТА АСКОРБИНОВАЯ
ПОВЕДЕНЧЕСКИЕ ВЛИЯНИЯ
ДОФАМИНЕРГИЧЕСКИЕ ВЛИЯНИЯ
МЫШИ

РЖ ВИНИТИ 34 (BI48) 95.11-04Т1.372

Dopaminergic neuronal systems modulate the central cardiovascular effects of TRH in rats [Text] / Jerzy Jedrusiak [et al.] // Pol. J. Pharmacol. - 1995. - Vol. 47, N 1. - P43-52 . - ISSN 1230-6002
Перевод заглавия: Дофаминергические нейронные системы модулируют центральные сердечно-сосудистые влияния тиролиберина у крыс
Аннотация: In rats thyrotropin releasing hormone (pGlu-His-Pro-NH[2] - TRH) produces an increase in blood pressure, heart rate and respiratory rate, following its intracerebroventricular (icv) administration. Because of a suspected role of the central dopamine (DA) system in these effects, we examined the influence of assorted DA receptor agonists and antagonists on the central cardiovascular and respiratory effects of TRH. Adult male Wistar rats were anesthetized with urethane (1.5 g/kg ip). TRH (100 nmol) produced a sustained increase in blood pressure, heart rate and respiratory rate during a 30 min observation period. The DA D[1] receptor agonist SKF 38393 HCl (0.3 or 3.0 mg/kg ip) attenuated the effects of TRH on blood pressure and heart rate by 50%, while the DA D[2] receptor agonist quinpirole HCl (1.0 mg/kg ip) potentiated the chronotropic response to TRH by 50%. The predominant DA D[2] receptor antagonist haloperidol lactate (1.0 mg/kg ip) potentiated the effects of TRH on blood pressure and heart rate by 50%, with the latter effect on heart rate being mimicked by the D[2] receptor antagonist spiperone HCl (1.0 mg/kg ip). Chlorpromazine HCl (5.0 mg/kg ip), a low potency nonselective D[2] receptor antagonist, had effects opposite to that of haloperidol. The effect of TRH on respiration was potentiated by quinpirole but not modified by other DA receptor agonists on antagonists. These findings indicate that the DA system is involved in a complex manner in the central cardiovascular actions of TRH, while DA D[2] receptors alone appear to be involved in modulating respiratory effects of TRH. Польша, Med. Acad., 41-808 Zabrze. Библ. 54

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.23.51 + 341.45.21.23.02
Рубрики: ТИРОЛИБЕРИН
ВНУТРИЖЕЛУДОЧКОВОЕ ВВЕДЕНИЕ
АРТЕРИАЛЬНОЕ ДАВЛЕНИЕ
ЧАСТОТА СЕРДЕЧНЫХ СОКРАЩЕНИЙ
ЧАСТОТА ДЫХАНИЯ
ДОФАМИНЕРГИЧЕСКИЕ ВЛИЯНИЯ
КРЫСЫ

Доп.точки доступа:
Jedrusiak, Jerzy; Brus, Ryszard; Kostrzewa, Richard M.; Slowinski, Zbigniew

РЖ ВИНИТИ 34 (BI48) 95.12-04Т2.175

Dopaminergic neuronal systems modulate the central cardiovascular effects of TRH in rats [Text] / Jerzy Jedrusiak [et al.] // Pol. J. Pharmacol. - 1995. - Vol. 47, N 1. - P43-52 . - ISSN 1230-6002
Перевод заглавия: Дофаминергические нейронные системы модулируют центральные сердечно-сосудистые влияния тиролиберина у крыс
Аннотация: In rats thyrotropin releasing hormone (pGlu-His-Pro-NH[2] - TRH) produces an increase in blood pressure, heart rate and respiratory rate, following its intracerebroventricular (icv) administration. Because of a suspected role of the central dopamine (DA) system in these effects, we examined the influence of assorted DA receptor agonists and antagonists on the central cardiovascular and respiratory effects of TRH. Adult male Wistar rats were anesthetized with urethane (1.5 g/kg ip). TRH (100 nmol) produced a sustained increase in blood pressure, heart rate and respiratory rate during a 30 min observation period. The DA D[1] receptor agonist SKF 38393 HCl (0.3 or 3.0 mg/kg ip) attenuated the effects of TRH on blood pressure and heart rate by 50%, while the DA D[2] receptor agonist quinpirole HCl (1.0 mg/kg ip) potentiated the chronotropic response to TRH by 50%. The predominant DA D[2] receptor antagonist haloperidol lactate (1.0 mg/kg ip) potentiated the effects of TRH on blood pressure and heart rate by 50%, with the latter effect on heart rate being mimicked by the D[2] receptor antagonist spiperone HCl (1.0 mg/kg ip). Chlorpromazine HCl (5.0 mg/kg ip), a low potency nonselective D[2] receptor antagonist, had effects opposite to that of haloperidol. The effect of TRH on respiration was potentiated by quinpirole but not modified by other DA receptor agonists on antagonists. These findings indicate that the DA system is involved in a complex manner in the central cardiovascular actions of TRH, while DA D[2] receptors alone appear to be involved in modulating respiratory effects of TRH. Польша, Med. Acad., 41-808 Zabrze. Библ. 54

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.65.15
Рубрики: ТИРОЛИБЕРИН
ВНУТРИЖЕЛУДОЧКОВОЕ ВВЕДЕНИЕ
АРТЕРИАЛЬНОЕ ДАВЛЕНИЕ
ЧАСТОТА СЕРДЕЧНЫХ СОКРАЩЕНИЙ
ЧАСТОТА ДЫХАНИЯ
ДОФАМИНЕРГИЧЕСКИЕ ВЛИЯНИЯ
КРЫСЫ

Доп.точки доступа:
Jedrusiak, Jerzy; Brus, Ryszard; Kostrzewa, Richard M.; Slowinski, Zbigniew

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