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РЖ ВИНИТИ 76 (BI29) 96.01-04Н1.203

Patthy, Miklos.
Separation of dihydroxybenzoates, indicators of in-vivo hydroxyl free radical formation, in the presence of transmitter amines and some metabolites in rodent brain, using high-performance liquid chromatography with electrochemical detection [Text] : [Pap.] Bio-Chromatogr. and Bio-Eng.: VTH Symp. Eur. Soc. Bio-Chromatogr., Nancy, May 17-19, 1994 / Miklos Patthy, istvan Kiraly, Istvan Sziraki // J. Chromatogr. Biomed. Appl. - 1995. - Vol. 664, N 1. - P247-252 . - ISSN 0378-4347
Перевод заглавия: Отделение дигидроксибензоатов, индикаторов образования гидроксильных свободных радикалов in vivo, в присутствии медиаторных аминов и некоторых метаболитов в мозгу грызунов с использованием высокоэффективной жидкостной хроматографии с электрохимической детекцией
Аннотация: Based on a detailed study of retention parameters, reversed-phase ion-pair chromatographic methods were developed for the simultaneous determination of dihydroxybenzoates, indicators of in-vivo hydroxyl free radical formation, transmitter amines and some metabolites to facilitate neurochemical investigations in rodent brain. Coupling of the separation methods with electrochemical detection and the use of short-chain perfluorinated carboxylic acids for ion-pairing, allowed for a fast and sensitive determination of salicylate-derived 2,3- and 2,5-dihydroxybenzoic acids and the major electroactive, hydroxylated aromatic compounds present in brain samples. Detection limits for the dihydroxybenzoates (signal-to-noise ratio-2) were 18-22 fmol injected on the column. Basal levels of 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate in the striatum of mice treated with salicylate were 72'+-'13 and 94'+-'11 ng/g wet tissue, respectively. Венгрия, Inst. Drug Res., Berline ut. 47-49, 1045 Budapest. Библ. 10

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.19.05
Рубрики: ДИГИДРОКСИБЕНЗОАТЫ
ОПРЕДЕЛЕНИЕ
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ
ВЫСОКОЭФФЕКТИВНАЯ ОБРАЩЕННОФАЗОВАЯ
МОЗГ
ГРЫЗУНЫ

Доп.точки доступа:
Kiraly, istvan; Sziraki, Istvan

РЖ ВИНИТИ 34 (BI48) 96.01-04Т2.240

Kountourellis, John E.
Reversed-phase high performance liquid chromatogrpahic determination of cyproheptadine from urine by solid-phase extraction [Text] / John E. Kountourellis, Kenneth O. Ebete // J. Chromatogr. Biomed. Appl. - 1995. - Vol. 664, N 2. - P468-471 . - ISSN 0378-4347
Перевод заглавия: Определение ципрогептадина в моче с помощью твердофазной экстракции и обращеннофазовой высокоэффективной жидкостной хроматографии
Аннотация: A simple, sensitive and reliable high-performance liquid chromatographic method for the determination of cyproheptadine in urine by solid-phase extraction (SPE) has been developed. The sample matrix was passed through a pre-conditioned C[18] cartridge, washed with methanol-water solution (4:1) and eluted with methanol. The methanolic solution was evaporated to dryness, reconstituted with methanol and chromatographed using a C[18] reversed-phase column. The mobile phase consisted of acetate buffer (constant ionic strength of 0.005 I)-methanol (56:44, v/v). Detection was performed at 254 nm with the sensitivity set at 0.002 AUFS. Concentrations as low as 50 ng/ml could be quantitatively determined by an external standard method and the overall recovery was found to be 76.15%, whereas the limit of detection was estimated as 15 ng/ml. Греция, Sch. Pharm., Lab. Pharm. Anal., Aristotelian Univ., 54006 Thessaloniki. Библ. 8

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.77.81.11
Рубрики: ЦИПРОГЕПТАДИН
ОПРЕДЕЛЕНИЕ
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ
ВЫСОКОЭФФЕКТИВНАЯ ОБРАЩЕННОФАЗОВАЯ
МОЧА
ЧЕЛОВЕК

Доп.точки доступа:
Ebete, Kenneth O.

РЖ ВИНИТИ 34 (BI34) 96.01-04Т4.272

Whiton, Robert S.
Improved high-performance liquid chromatographic method for the determination of polycyclic aromatic hydrocarbon metabolites in human urine [Text] / Robert S. Whiton, Carlton L. Witherspoon, Timothy J. Buckley // J. Chromatogr. Biomed. Appl. - 1995. - Vol. 665, N 2. - P390-394 . - ISSN 0378-4347
Перевод заглавия: Усовершенствованный метод определения метаболитов полициклических ароматических углеводородов в моче человека с помощью высокоэффективной жидкостной хроматографии
Аннотация: A reversed-phase HPLC method with fluorescence detection was evaluated for utility in determination of urinary metabolites of polycyclic aromatic hydrocarbons as biomarkers of environmental exposure. The method, which was developed for use in studies of high-level occupational exposure, was found to be unreliable for relatively low-level environmental exposures. The method was modified to include quantitation by standard addition in order to compensate for matrix effects at levels as low as 0.1 ng/ml. The standard addition modification increased both qualitative and quantitative performance, with recovery of 1-hydroxypyrene spiked improved from 164% to 114% at 0.36 ng/ml. The modified method was successfully applied in an environmental exposure study. США, ManTech Env. Technol., POB 12313, 2 Triangle Drive, Res. Triangle Park, NC 27709. Библ. 8

ГРНТИ	34.47.51

ВИНИТИ 341.47.51.05
Рубрики: 1-ГИДРОКСИПИРЕН
3-ГИДРОКСИБЕНЗ(А)ПИРЕН
3-ГИДРОКСИБЕНЗ(А)АНТРАЦЕН
ОПРЕДЕЛЕНИЕ
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ
ВЫСОКОЭФФЕКТИВНАЯ ОБРАЩЕННОФАЗОВАЯ
МОЧА
ЧЕЛОВЕК

Доп.точки доступа:
Witherspoon, Carlton L.; Buckley, Timothy J.

РЖ ВИНИТИ 76 (BI34) 96.01-04Т4.579

Kountourellis, John E.
Reversed-phase high performance liquid chromatogrpahic determination of cyproheptadine from urine by solid-phase extraction [Text] / John E. Kountourellis, Kenneth O. Ebete // J. Chromatogr. Biomed. Appl. - 1995. - Vol. 664, N 2. - P468-471 . - ISSN 0378-4347
Перевод заглавия: Определение ципрогептадина в моче с помощью твердофазной экстракции и обращеннофазовой высокоэффективной жидкостной хроматографии
Аннотация: A simple, sensitive and reliable high-performance liquid chromatographic method for the determination of cyproheptadine in urine by solid-phase extraction (SPE) has been developed. The sample matrix was passed through a pre-conditioned C[18] cartridge, washed with methanol-water solution (4:1) and eluted with methanol. The methanolic solution was evaporated to dryness, reconstituted with methanol and chromatographed using a C[18] reversed-phase column. The mobile phase consisted of acetate buffer (constant ionic strength of 0.005 I)-methanol (56:44, v/v). Detection was performed at 254 nm with the sensitivity set at 0.002 AUFS. Concentrations as low as 50 ng/ml could be quantitatively determined by an external standard method and the overall recovery was found to be 76.15%, whereas the limit of detection was estimated as 15 ng/ml. Греция, Sch. Pharm., Lab. Pharm. Anal., Aristotelian Univ., 54006 Thessaloniki. Библ. 8

ГРНТИ	76.35.45

ВИНИТИ 761.35.45.05
Рубрики: ЦИПРОГЕПТАДИН
ОПРЕДЕЛЕНИЕ
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ
ВЫСОКОЭФФЕКТИВНАЯ ОБРАЩЕННОФАЗОВАЯ
МОЧА
ЧЕЛОВЕК

Доп.точки доступа:
Ebete, Kenneth O.

РЖ ВИНИТИ 76 (BI28) 96.02-04Н3.43

Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase hith-performance liquid chromatography [Text] / Alexander Sparreboom [et al.] // J. Chromatogr. Biomed. Appl. - 1995. - Vol. 664, N 2. - P383-391 . - ISSN 0378-4347
Перевод заглавия: Определение паклитаксела и [его] метаболитов в плазме [крови], тканях, моче и фекалиях мышей с помощью полуавтоматизированной обращеннофазовой высокоэффективной жидкостной хроматографии
Аннотация: We have developed and validated a sensitive and selective assay for the quantification of paclitaxel and its metabolites 6'альфа'.3'-p-duhydroxypaclitaxel. 3'-p-hydroxypaclitaxel and 6'альфа'-hydroxypaclitaxel in plasma, tissue, urine and faeces specimens of mice. Tissue and faeces were homogenized (approximately 0.1-0.2 g/ml) in bovine serum albumin (40 g/l) in water, and urine was diluted (1:5, v/v) in blank human plasma. Sample pretreatment involved liqui-liquid extraction of 200-1000 'мю'l of sample with diethyl ether followed by automated solid-phase extraction using cyano Bond Elut columns. 2'-Methylpaclitaxel was used as internal standard. The overall recovery of the sample pretreatment procedure ranged from 76 to 85%. In plasma, the lower limit of detection (LOD) and the lower limit of quantitation (LLQ) are 15 and 25 ng/ml, respectively, using 200 'мю'l of sample. In tissues, faeces and urine the LLQs are 25-100 ng/g. 125 ng/g and 25 ng/ml, respectively, using 1000 'мю'l (faeces; 200 'мю'l) of homogenized or diluted sample. The concentrations in the various biological matrices, for validation procedures spiked with known amounts of the test compounds, are read from calibration curves constructed in blank human plasma in the range 25-100 000 ng/ml for paclitaxel and 25-500 ng/ml for the metabolites. The accuracy and precision of the assay fall within the generaly accepted criteria for bio-analytical assays. Нидерланды, Dep. Clin. Chem., Antoni van Leeuwenhoek Huis, NL Canc. Inst., Plesmanlaan 121, 1066 CX Amsterdam. Библ. 27

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.55.07.05
Рубрики: ПАКЛИТАКСЕЛ
МЕТАБОЛИТЫ
ОПРЕДЕЛЕНИЕ
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ
ВЫСОКОЭФФЕКТИВНАЯ ОБРАЩЕННОФАЗОВАЯ
КРОВЬ, МОЧА, ФЕКАЛИИ, МОЗГ, ПЕЧЕНЬ, ЛЕГКИЕ, СЕРДЦЕ, ПОЧКИ, СЕЛЕЗЕНКА, КИШЕЧНИК, ЯИЧНИКИ, МАТКА
МЫШИ

Доп.точки доступа:
Sparreboom, Alexander; Tellingen, Olaf van; Nooijen, Willem J.; Beijnen, Jos H.

РЖ ВИНИТИ 34 (BI48) 96.02-04Т1.63

Kountourellis, John E.
Reversed-phase high performance liquid chromatogrpahic determination of cyproheptadine from urine by solid-phase extraction [Text] / John E. Kountourellis, Kenneth O. Ebete // J. Chromatogr. Biomed. Appl. - 1995. - Vol. 664, N 2. - P468-471 . - ISSN 0378-4347
Перевод заглавия: Определение ципрогептадина в моче с помощью твердофазной экстракции и обращеннофазовой высокоэффективной жидкостной хроматографии
Аннотация: A simple, sensitive and reliable high-performance liquid chromatographic method for the determination of cyproheptadine in urine by solid-phase extraction (SPE) has been developed. The sample matrix was passed through a pre-conditioned C[18] cartridge, washed with methanol-water solution (4:1) and eluted with methanol. The methanolic solution was evaporated to dryness, reconstituted with methanol and chromatographed using a C[18] reversed-phase column. The mobile phase consisted of acetate buffer (constant ionic strength of 0.005 I)-methanol (56:44, v/v). Detection was performed at 254 nm with the sensitivity set at 0.002 AUFS. Concentrations as low as 50 ng/ml could be quantitatively determined by an external standard method and the overall recovery was found to be 76.15%, whereas the limit of detection was estimated as 15 ng/ml. Греция, Sch. Pharm., Lab. Pharm. Anal., Aristotelian Univ., 54006 Thessaloniki. Библ. 8

ГРНТИ	34.45.15

ВИНИТИ 341.45.15.09.05
Рубрики: ЦИПРОГЕПТАДИН
ОПРЕДЕЛЕНИЕ
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ
ВЫСОКОЭФФЕКТИВНАЯ ОБРАЩЕННОФАЗОВАЯ
МОЧА
ЧЕЛОВЕК

Доп.точки доступа:
Ebete, Kenneth O.

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