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РЖ ВИНИТИ 34 (BI39) 96.07-04К1.152

Hagerty, David T.
Intramolecular mimicry. Identification and analysis of two cross-reactive T cell epitopes within a single protein [Text] / David T. Hagerty, Paul M. Allen // J. Immunol. - 1995. - Vol. 155, N 6. - P2993-3001 . - ISSN 0022-1767
Перевод заглавия: Внутриклеточная мимикрия. Идентификация и анализ двух перекрестно-реактивных Т-клеточных эпитопов в одном белке
Аннотация: The recognition of peptide Ags by T cells through the TCR has exquisite specificity. Cross-reactive T cell responses have been described. Two peptides derived from the same protein can exhibit sufficient structural homology, despite minimal structural identity, to elicit cross-reactive T cell responses. Were investigated the structural basis for cross-reactivity. T cell hybridomas recognizing PiM and PiZ allelic forms of human 'альфа'[1]-antitrypsin each recognized both PiM 205-220 and PiM 335-350. These two peptides possessed primary sequence identity at only two of 16 amino acid residues. Cross-reactive peptides also exhibited homology at the bulk T cell level because lymph node T cells primed with one peptide proliferated to the other peptide in vitro. Critical amino acids for the responding T cells were determined, and the core was transferred into the less reactive peptide in an attempt to increase homology by increasing sequence identity. Interestingly, as identity increased, homology decreased: peptides with the least primary sequence identity appeared most homologous to the T cells. These results have important implications for understanding the development of autoimmune diseases. The ability of structurally dissimilar peptides to mimic each other when bound to a class II MHC molecule may also be important to the inderstanding of T development and autoimmunity. США, Dep. Pathol., Washington Univ. Med. Sch., St. Louis, MO 63110. Библ. 36

ГРНТИ	34.43.29

ВИНИТИ 341.43.29.11
Рубрики: АНТИТРИПСИН АЛЬФА 1 ЧЕЛОВЕКА
ПЕПТИДЫ 205-220 И 335-350
ЛИМФОЦИТЫ T
РЕЦЕПТОРЫ
ПЕРЕКРЕСТНАЯ РЕАКЦИЯ С ПЕПТИДАМИ
МЕХАНИЗМЫ РАСПОЗНАВАНИЯ
АНТИГЕНЫ КЛАССА II ГКГС

Доп.точки доступа:
Allen, Paul M.

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