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РЖ ВИНИТИ 34 (BI39) 96.04-04К1.117

Wang, Le.
Human anti-gal heavy chain genes: Preferential use of V[H]3 and the presence of somatic mutations [Text] / Le Wang, |Marko Z. Radic, Uri Galili // J. Immunol. - 1995. - Vol. 155, N 3. - P1276-1285 . - ISSN 0022-1767
Перевод заглавия: Гены тяжелых цепей антител против галактозы человека. Преимущественное использование V[H]3 и наличие соматических мутаций
Аннотация: Anti-Gal is the most abundant natural Ab known in humans. It interacts specifically with the carbohydrate structure Gal'альфа'1-3Gal'бета'1-4GlcNAc-R (termed the 'альфа'-galactosyl epitope), constitutes approximately 1% of circulating Ig, and is found in all three isotypes in the serum. Anti-Gal is produced in Old World monkeys, apes, and humans, and in no other mammalian species. The objective of this study was to determine the V[H] genes involved in the synthesis of anti-Gal. B lymphocytes from various individuals were transformed by EBV, the clones producing anti-Gal were isolated, the specificity and affinity of the Abs were determined, and the V[H] genes were sequenced. Eight of the nine clones studied used V[H]3 family genes and one clone used a V[H]1 favily gene. Four of the five V[H]3 genes used were found to form a cluster of related sequences. Comparison with known germline sequences for all of the clones studied and analysis of autologous germ-line genes in two of the clones indicate that anti-Gal V[H] genes undergo somatic mutations. These somatic mutations may provide a pool of variants that are available for affinity maturation. США, Dep. Microbiol., Med College Pennsylvania, Univ. Philadelphia, PA 19129. Библ. 67

ГРНТИ	34.43.33

ВИНИТИ 341.43.33.09
Рубрики: АНТИТЕЛА ПРОТИВ ГАЛАКТОЗЫ
ТЯЖЕЛАЯ ЦЕПЬ
ГЕНЕТИЧЕСКИЙ КОНТРОЛЬ СИНТЕЗА
СИНТЕЗИРУЮЩИЕ КЛОНЫ ЛИМФОЦИТОВ B
ЧЕЛОВЕК

Доп.точки доступа:
Radic, |Marko Z.; Galili, Uri

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