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РЖ ВИНИТИ 76 (BI29) 96.05-04Н1.139

Growth factor expression and proliferation kinetics in periampullary neoplasms in familial adenomatous polyposis [Text] / Murray B. Resnick [et al.] // Cancer. - 1995. - Vol. 76, N 2. - P187-194 . - ISSN 0008-543X
Перевод заглавия: Экспрессия фактора роста и кинетика пролиферации в периампулярных новообразованиях при семейном аденоматозном полипозе
Аннотация: Authors systematically evaluated the expression of the intestinal peptide growth factor, transforming growth factor-alpha (TGF-alpha), and its corresponding receptor, epidermal growth factor-receptor (EGF-R), in 49 periampullary adenomas and 6 periampullary carcinomas from 29 patients. Tumor proliferation rates were evaluated with the MIB-1 antibody. All periampullary adenomas and carcinomas (100%) had TGF-alpha expression, whereas 63% of adenomas and 67% of carcinomas expressed EGF-R. The extent of TGF-alpha expression was greater in carcinomas compared with adenomas and increased progressively in adenomas relative to the degree of dysplasia and villous architecture of these lesions. The extent of EGF-R expression correlated only with the degree of dysplasia in adenomas. With regard to proliferation kinetics, higher MIB-1 labeling indices were observed in adenomas that were larger, more severely dysplastic, and villous. Transforming growth factor-alpha, and to a lesser extent, EGF-R expression, correlated directly with the MIB-1 labeling indices. These results support the adenoma-carcinoma sequence in the progression of malignancy in the duodenum in familial adenomatous polyposis, suggesting a possible involvement for TGF-alpha and EGF-R expression in this process. Библ. 40

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.15.25.25
Рубрики: АДЕНОМАТОЗ ПОЛИПОЗНЫЙ
СЕМЕЙНЫЙ
ФАКТОРЫ РОСТА
КИНЕТИКА ПРОЛИФЕРАЦИИ
НОВООБРАЗОВАНИЕ ПЕРИАМПУЛЯРНОЕ
ЧЕЛОВЕК

Доп.точки доступа:
Resnick, Murray B.; Gallinger, Steven; Wang, Helen H.; Odze, Robert D.

РЖ ВИНИТИ 76 (BI40) 96.06-04М7.131

Growth factor expression and proliferation kinetics in periampullary neoplasms in familial adenomatous polyposis [Text] / Murray B. Resnick [et al.] // Cancer. - 1995. - Vol. 76, N 2. - P187-194 . - ISSN 0008-543X
Перевод заглавия: Экспрессия фактора роста и кинетика пролиферации в периампулярных новообразованиях при семейном аденоматозном полипозе
Аннотация: Authors systematically evaluated the expression of the intestinal peptide growth factor, transforming growth factor-alpha (TGF-alpha), and its corresponding receptor, epidermal growth factor-receptor (EGF-R), in 49 periampullary adenomas and 6 periampullary carcinomas from 29 patients. Tumor proliferation rates were evaluated with the MIB-1 antibody. All periampullary adenomas and carcinomas (100%) had TGF-alpha expression, whereas 63% of adenomas and 67% of carcinomas expressed EGF-R. The extent of TGF-alpha expression was greater in carcinomas compared with adenomas and increased progressively in adenomas relative to the degree of dysplasia and villous architecture of these lesions. The extent of EGF-R expression correlated only with the degree of dysplasia in adenomas. With regard to proliferation kinetics, higher MIB-1 labeling indices were observed in adenomas that were larger, more severely dysplastic, and villous. Transforming growth factor-alpha, and to a lesser extent, EGF-R expression, correlated directly with the MIB-1 labeling indices. These results support the adenoma-carcinoma sequence in the progression of malignancy in the duodenum in familial adenomatous polyposis, suggesting a possible involvement for TGF-alpha and EGF-R expression in this process. Библ. 40

ГРНТИ	76.03.49

ВИНИТИ 761.03.49.29.25
Рубрики: АДЕНОМАТОЗ ПОЛИПОЗНЫЙ
СЕМЕЙНЫЙ
ФАКТОРЫ РОСТА
КИНЕТИКА ПРОЛИФЕРАЦИИ
НОВООБРАЗОВАНИЕ ПЕРИАМПУЛЯРНОЕ
ЧЕЛОВЕК

Доп.точки доступа:
Resnick, Murray B.; Gallinger, Steven; Wang, Helen H.; Odze, Robert D.

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