СибНСХБ

Вид поиска

Область поиска

Найдено в других БД

Формат представления найденных документов:
библиографическое описание	краткий	полный

Отсортировать найденные документы по:
автору	заглавию	году издания	типу документа

Поисковый запрос: (<.>A=Zusman, Rivka$<.>)

Общее количество найденных документов : 3
Показаны документы с 1 по 3

РЖ ВИНИТИ 34 (BI13) 96.07-04Б3.16

Zusman, Rivka.
Gel fibreglass as a new support for affinity chromatography [Text] / Rivka Zusman, Igor Zusman // Biotechnol. and Appl. Biochem. - 1995. - Vol. 21, N 2. - P161-172 . - ISSN 0885-4513
Перевод заглавия: Гель из стекловолокна в качестве нового носителя для аффинной хроматографии
Аннотация: Недавно изобретен новый носитель из стекловолокна для аффинной хроматографии. Носитель представляет собой стекловолоконный гелевый матрикс, покрытый оксисиланом. Посредством дериватизации неспецифическая сорбция белков на носителе сведена к минимуму; на поверхности решетки стекловолоконного геля создан тонкий слой белка, включенного в стекловолокно. Агенты, находящиеся в анализируемом образце, при диффузии последнего через носитель взаимодействуют с макс. числом молекул включенных в стекловолокно соединений. Носитель очень стоек и в сухом состоянии может храниться при комнатной т-ре в течение нескольких месяцев. Израиль, Lab. Teratol. and Experimental Oncol. The Koret Sch. Veterenary Med. The Hebrew Univ. Jerusalem, Rehovot, P.O. Box 12, Israel 76100. Библ. 27

ГРНТИ	34.27.39

ВИНИТИ 341.27.39.07.02
Рубрики: АФФИННАЯ ХРОМАТОГРАФИЯ
НОСИТЕЛЬ ИЗ СТЕКЛОВОЛОКНА
РАЗРАБОТКА УСОВЕРШЕНСТВЕННОГО МЕТОДА

Доп.точки доступа:
Zusman, Igor

РЖ ВИНИТИ 76 (BI28) 96.12-04Н3.233

IgG generated against benign tumor-associated antigens prevented the effects of 1,2-dimethylhydrazine in rats [Text] / Igor Zusman [et al.] // Anticancer Res. - 1996. - Vol. 16, N 3a. - P1183-1186 . - ISSN 0250-7005
Перевод заглавия: Образование IgG против антигенов ассоциированных с доброкачественными опухолями предотвращает воздействие 1,2-диметилгидразина на крыс
Аннотация: It was showed the possibility of significant decreasing of the frequency of chemically induced colon cancer in rats by vaccination with polyclonal rabbit IgG generated against purified tumor-associated antigens (TAA). TAA were isolated from benign rat colon tumors by the method developed in the laboratory (Zusman et al 1994) using affinity chromatography columns with gel fiberglass membranes (R. Zusman, 1992) containing anti-tumor IgG. The IgG was isolated from rabbits following their vaccination with TAA. Sprague Dawley rats were vaccinated with anti-TAA IgG (100 'мю'g/rat) suspended in Freunds adjuvant by weekly subcutaneous injections for 5 weeks. The induction of colon cancer was caused by weekly injections with 1,2-dimethylhydrazine (DMH) (20 mg/kg) for 7 weeks and was started one week after the end of the vaccination. The results of experiments were evaluated 6 months after the start of cancer induction. IgG protected against the carcinogenic effects of DMH. The number of tumor-bearing rats decreased to 64% as compared with 90% in the control group. In vaccinated rats, the incidence of tumors was almost 3 times less than of control, i. e. 3.6 and 9.3, respectively. The number of malignant tumors was also significantly smaller in vaccinated rats than in controls, being 24% and 58%, respectively. Metastases were found only in controls, 4 of 30 rats. The results of these experiments have shown that anti-TAA IgG not only has anti-tumor effects but also prevents the malignization of benign tumors. As one of the main components of TAA which was isolated from colon cancer rats was soluble p53 antigen (Zusman et al 1994), it was suggest that the vaccine which has been generated in our experiments may be regarded as acting mainly against p53 antigen, and its antitumor effects should also be considered as effects of p53 antibodies. The further studies will be performed to clarify this. Библ. 31

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.55.11.17
Рубрики: АНТИГЕНЫ ОПУХОЛЕАССОЦИИРОВАННЫЕ
ОПУХОЛИ ДОБРОКАЧЕСТВЕННЫЕ
ИММУНОГЛОБУЛИНЫ
ВАКЦИНАЦИЯ
КАНЦЕРОГЕНЕЗ ХИМИЧЕСКИЙ
КРЫСЫ

Доп.точки доступа:
Zusman, Igor; Zusman, Rivka; Korol, Dorina; Gurevich, Pavel

РЖ ВИНИТИ 76 (BI29) 97.01-04Н1.373

IgG generated against benign tumor-associated antigens prevented the effects of 1,2-dimethylhydrazine in rats [Text] / Igor Zusman [et al.] // Anticancer Res. - 1996. - Vol. 16, N 3a. - P1183-1186 . - ISSN 0250-7005
Перевод заглавия: Образование IgG против антигенов ассоциированных с доброкачественными опухолями предотвращает воздействие 1,2-диметилгидразина на крыс
Аннотация: It was showed the possibility of significant decreasing of the frequency of chemically induced colon cancer in rats by vaccination with polyclonal rabbit IgG generated against purified tumor-associated antigens (TAA). TAA were isolated from benign rat colon tumors by the method developed in the laboratory (Zusman et al 1994) using affinity chromatography columns with gel fiberglass membranes (R. Zusman, 1992) containing anti-tumor IgG. The IgG was isolated from rabbits following their vaccination with TAA. Sprague Dawley rats were vaccinated with anti-TAA IgG (100 'мю'g/rat) suspended in Freunds adjuvant by weekly subcutaneous injections for 5 weeks. The induction of colon cancer was caused by weekly injections with 1,2-dimethylhydrazine (DMH) (20 mg/kg) for 7 weeks and was started one week after the end of the vaccination. The results of experiments were evaluated 6 months after the start of cancer induction. IgG protected against the carcinogenic effects of DMH. The number of tumor-bearing rats decreased to 64% as compared with 90% in the control group. In vaccinated rats, the incidence of tumors was almost 3 times less than of control, i. e. 3.6 and 9.3, respectively. The number of malignant tumors was also significantly smaller in vaccinated rats than in controls, being 24% and 58%, respectively. Metastases were found only in controls, 4 of 30 rats. The results of these experiments have shown that anti-TAA IgG not only has anti-tumor effects but also prevents the malignization of benign tumors. As one of the main components of TAA which was isolated from colon cancer rats was soluble p53 antigen (Zusman et al 1994), it was suggest that the vaccine which has been generated in our experiments may be regarded as acting mainly against p53 antigen, and its antitumor effects should also be considered as effects of p53 antibodies. The further studies will be performed to clarify this. Библ. 31

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.23.09.02
Рубрики: АНТИГЕНЫ ОПУХОЛЕАССОЦИИРОВАННЫЕ
ОПУХОЛИ ДОБРОКАЧЕСТВЕННЫЕ
ИММУНОГЛОБУЛИНЫ
ВАКЦИНАЦИЯ
КАНЦЕРОГЕНЕЗ ХИМИЧЕСКИЙ
КРЫСЫ

Доп.точки доступа:
Zusman, Igor; Zusman, Rivka; Korol, Dorina; Gurevich, Pavel

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

rtvarBDview(" результаты поиска","20190607010228","4682442");

Вид поиска