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РЖ ВИНИТИ 34 (BI49) 97.02-04Я6.230

Waard, Michel de.
Functional properties of the purified N-type Ca{2+} channel from rabbit brain [Text] / Michel de Waard, Derrick R. Witcher, Kevin P. Campbell // J. Biol. Chem. - 1994. - Vol. 269, N 9. - P6716-6724 . - ISSN 0021-9258
Перевод заглавия: Функциональные свойства очищенных Ca{2+}-каналов N-типа из головного мозга кролика
Аннотация: N-type Ca{2+} channels control a veriety of key neuronal functions including transmitter release at synaptic terminals. The purified 'омега'-conotoxin receptor from rabbit brain is a multisubunit complex composed of 'альфа'[1B], 'альфа'[2]'дельта', 'бета'[3], and 95-kDa subunits. Immunoadsorption experiments confirm that the purified preparation does not contain 'альфа'[1] subunits other than the 'омега'-conotoxin-sensitive class B isoform. The functional properties of the purified channel have been analyzed further in lipid bilayers, and similarities to or differences from the native N-type Ca{2+} channel have been outlined. Conserved properties include ion selectivity, open-time duration, and pharmacology (insensitivity to drugs affecting skeletal muscle L-type Ca{2+} channels). Observed properties of the reconstituted channel which differ from the native channel include (a) sustained channel activity without Ca{2+} or coltage-induced inactivation; (b) examples of extremely high open-state probability; (c) the absence of "rundown"; and (d) voltage independence of the Ca{2+} channel gating. In addition, the conductance of the purified receptor is comprised between 7 and 27 picosiemens. Our results suggest that cellular components may play critical roles in the regulation of several biophysical properties and neuronal function of the native N-type Ca{2+} channel. США, Howard Hughes Med. Inst., Dep. Physiol. and Biophys., Univ Iowa Coll. Med., Iowa 52242. Библ. 51

ГРНТИ	34.19.19

ВИНИТИ 341.19.19.19
Рубрики: КАЛЬЦИЕВЫЕ КАНАЛЫ
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ФУНКЦИОНАЛЬНЫЕ СВОЙСТВА
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Доп.точки доступа:
Witcher, Derrick R.; Campbell, Kevin P.

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