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РЖ ВИНИТИ 76 (BI29) 95.10-04Н1.359

La, Porta A. M.
Membrane and nuclear protein kinase C activation in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis [Text] / Porta A. M. La, R. Comolli // Carcinogenesis. - 1994. - Vol. 18, N 5. - P1743-1747 . - ISSN 0143-3334
Перевод заглавия: Активация мембранной и ядерной протеинкиназы С на ранних стадиях индуцированного диэтилнитрозамином гепатоканцерогенеза крыс
Аннотация: The activity and expression of Ca{2}{+}-dependent cPKC 'альфа' and 'бета' isoenzymes in the particulate, soluble (cytosolic) and nuclear fractions of rat liver and the expression of Ca{2}{+}independent nPKC 'дельта' and aPKC 'дзета' were examined during the early stages (30 and 60 min, 24 and 96 h and 7 and 60 days post-hepatectomy) of the Solt-Farber 'resistant hepatocyte' model of diethylnitrosamine (DENA)-induced hepatocarcinogenesis in Fischer 344 rats and related to the presence of 'гамма'-glutamyl transpeptidase (GGT)-positive hyperplastic cell foci and persistent nodules in rat liver. Total PKC activity was unmodified by the carcinogenic treatment. In contrast, the PKC activity in the particulate, as well as nuclear fractions increased with time, reaching a maximum 60 days post-hepatectomy, with a decrease in the cytosolic activity. In carcinogen-treated animals maximal expression of cPKC 'альфа' and 'бета' isoenzymes was present 7 days post-hepatectomy, while no changes in nPKC 'дельта' and aPKC 'дзета' immunoreactivity were detected. In the nucleus, no cPKC 'альфа' isoform expression was observed, the cPKC 'бета' expression being maximal at 60 days. Seven and 60 days post-hepatectomy GGT-positive hyperplastic cell foci and persistent nodules were present in rat liver respectively. Taken together, the results of this study suggest a role for nuclear cPKC 'бета' and for cPKC 'альфа' in promoting the selective growth of carcinogen-initiated hepatocytes in rat liver. No evidence for a role of Ca{2}{+}-independent nPKC 'дельта' and aPKC 'дзета' isoenzymes in the early stages of DENA-induced liver carcinogenesis could be demonstrated. Италия, Dep. of General Physiology and Biochemistry, Section of General Pathology, Univ. of Milan, Milano, via Geloria 26, I-20133. Библ. 42.

ГРНТИ	76.29.49

ВИНИТИ 761.29.49.21.17.02
Рубрики: ПРОТЕИНКИНАЗА С
МЕМБРАНЫ КЛЕТОЧНЫЕ
ЯДРО КЛЕТОЧНОЕ
КАНЦЕРОГЕНЕЗ ХИМИЧЕСКИЙ
ДИЭТИЛНИТРОЗАМИН
ПЕЧЕНЬ
ОБЗОРЫ
БИБЛ. 42
КРЫСЫ

Доп.точки доступа:
Comolli, R.

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