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РЖ ВИНИТИ 34 (BI24) 96.09-04М3.314

Cell-specific differential expression of Na{+} channel 'бета'1-subunit mRNA in the olfactory system during postnatal development and after denervation [Text] / Shunsuke Sashihara [et al.] // J. Neurosci. - 1996. - Vol. 16, N 2. - P702-713 . - ISSN 0270-6474
Перевод заглавия: Различная экспрессия мРНК 'бета'1-субъединицы Na{+}-каналов, специфичная для клеток, в обонятельной системе при постнатальном развитии и после денервации
Аннотация: The authors investigated the developmental and denervation-induced regulation of the Na{+}-channel 'бета'1 subunit (Na'бета'1) in rat olfactory bulb (OB) and piriform cortex (PC). In situ hybridization shows that Na'бета'1 mRNA expression is upregulated developmentally, but with different time courses in mitral, tufted, and pyramidal cells. In mitral cells, label was detected at postnatal day 4 (P4) and gradually increased to P14. Tufted cells were devoid of Na'бета'1 mRNA before P14, when most cells expressed adult levels. In pyramidal cells of PC, Na'бета'1 expression was not detectable clearly until P14, with maximal expression at P28. To examine the regulation of Na'бета'1 mRNA, the authors surgically deafferented the OB at P30 and compared the effects on Na'бета'1 with those for Na{+}-channel 'альфа'-subunit (Na'альфа') mRNAs. Within 5d of surgery, the Na'бета'1 and Na'альфа'II signals within tufted cells disappeared almost completely. Na'бета'1 and Na'альфа'II expression was decreased in mitral cells to low-to-moderate levels. In pyramidal cells, Na'бета'1 mRNA expression was decreased moderately without significant changes in Na'альфа'II mRNA. Deafferentation had no detectable effects on Na'альфа'I or III mRNAs in either OB or PC. These data indicate that Na'бета'1 mRNA is expressed differentially in subpopulations of cells in the olfactory system during development and after deafferentation and suggest that the expression of Na'бета'1 is regulated independently of Na'альфа' mRNAs via cell-specific and pathway-specific mechanisms. Библ. 65

ГРНТИ	34.39.15

ВИНИТИ 341.39.15.37.17.13
Рубрики: НАТРИЕВЫЕ КАНАЛЫ
ЭКСПРЕССИЯ МРНК СУБЪЕДИНИЦ
ГИБРИДИЗАЦИЯ IN SITU
ОБОНЯТЕЛЬНАЯ ЛУКОВИЦА
ПИРИФОРМНАЯ КОРА
ПИРАМИДНЫЕ КЛЕТКИ
ПОСТНАТАЛЬНОЕ РАЗВИТИЕ
ДЕНЕРВАЦИЯ
КРЫСЫ

Доп.точки доступа:
Sashihara, Shunsuke; Greer, Charles A.; Oh, Youngsuk; Waxman, Stephen G.

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