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РЖ ВИНИТИ 34 (BI34) 95.10-04Т4.38

Lailey, Alison F.
Thiol levels in rat bronchio-alveolar lavage fluid after administration of cysteine esters [Text] / Alison F. Lailey, David G. Upshall // Hum. and Exp. Toxicol. - 1994. - Vol. 13, N 11. - P776-780 . - ISSN 0144-5952
Перевод заглавия: Уровни тиола в бронхоальвеолярном смыве крыс после введения им цистеиновых эфиров
Аннотация: The intraperitoneal administration of cysteine, N-acetylcysteine, the methyl, isopropyl, cyclo pentyl, neo pentyl, cyclo hexyl and tertiary butyl esters of cysteine and of cystine dimethyl ester increased the levels of total non-protein sulphydryls and cysteine in the bronchioalveolar lavage fluid and plasma of rats. In all cases the non-protein sulphydryl levels reflected the increased cysteine levels. Cysteine N-acetylcysteine, the cysteine esters and cystine dimethyl ester raised the levels of non-protein sulphydryls and hence cysteine in the bronchioalveolar lining fluid as follows: CIPECCPECMECDMECneoPECCHENacCySH CTBE. Plasma levels of NPSH were increased as follows: NacCySH CCPECCHECneoPECIPECMECDMECTBE. All except CTBE have been shown to protect against the lethal effects of inhaled perfluoroisobutene, a pyrolysis product of polytetrafluoroethene which induces a fulminating pulmonary oedema. This study showed that by raising the levels of thiols in the bronchioalveolar lavage fluid (BALF), the epithelial cells lining the bronchiolar, alveolar regions of the lung could be protected against inhaled toxicants. It is proposed that increased thiol levels in the BALF may contribute to the overall protection induced by these compounds by reacting with inhaled electrophiles to prevent or reduce damage to tissue in close proximity to the airways. Великобритания, Chem. and Biol. Defence Establishment, Porlon Down., Wills. Ил. 6. Библ. 10

ГРНТИ	34.47.03

ВИНИТИ 341.47.03.17
Рубрики: ЦИСТЕИНОВЫЕ ЭФИРЫ
ЛЕГКИЕ
БРОНХОАЛЬВЕОЛЯРНЫЙ ЛАВАЖ
ТИОЛЫ
ХИМИЧЕСКИЕ СОЕДИНЕНИЯ
ТОКСИЧНОСТЬ
ЗАЩИТНОЕ ДЕЙСТВИЕ

Доп.точки доступа:
Upshall, David G.

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