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РЖ ВИНИТИ 34 (BI48) 96.07-04Т2.320

Effect of the antiretroviral agent hypericin on rat liver mitochondria [Text] / Takahiko Utsumi [et al.] // Biochem. Pharmacol. - 1995. - Vol. 50, N 5. - P655-662 . - ISSN 0006-2952
Перевод заглавия: Действие противоретровирусного средства гиперицина на митохондрии печени крыс
Аннотация: The photosensitizing effect of hypericin (HY), an antiretroviral agent, on the functions of isolated rat liver mitochondria has been investigated. The respiratory control ratio (RCR), ADP/O and membrane potential of mitochondria were decreased by HY in a light-dependent manner. Uncoupled respiration of mitochondia in the presence of succinate was also inhibited by HY in a lightdependent manner. The ID[50] of hypericin for these inhibitions was approximately 0.5 'мю'M. These inhibitory effects of HY were not observed when photosensitization was conducted under anaerobic conditions and were not affected by desferrioxamine (DSF) or superoxide dismutase (SOD). Upon photosensitization of HY, mitochondria consumed oxygen in the absence of respiratory substrate with concomitant of thiobarbituric acid reactive substance (TBARS). The amount of oxygen consumed was 100-times greater than that of formation TBARS formed. The oxygen uptake was partially inhibited by NaN[3], and formation of TBARS was inhibited by DSF. Upon photosensitization of HY in the presence of mitochondrial membranes, the electron spin resonance (ESR) signal of 2,2-dimethyl-5-hydroxy-1-pyrrolidinyloxyl (DMPO/* OH) was increased by a mechanism which was suppressed by DSF. An ESR signal for singlet oxygen bound to 2,5-dimethylfuran,2,2,6,6-tetramethyl-4-piperidone (TEMP) was also detected under light in the presence of mitochondria. This signal of the TEMP-N-oxyl radical (TEMPO) was decreased by azide, which physically quenches singlet oxygen, but was increased by DSF. These results indicate that HY might inhibit mitochondrial functions by a type II photodynamic mechanism but that lipid peroxidation of biological membranes through an active oxygenmediated photodynamic mechanism is not involved. Япония, The First Division, Depart. of Internal Medicine, Fac. of Medicine, Kyoto Univ., Kyoto 606-01. Библ. 32

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.47.17
Рубрики: ПРОТИВОВИРУСНЫЕ СРЕДСТВА
ГИПЕРИЦИН
ПЕЧЕНЬ КРЫС
МИТОХОНДРИИ
IN VITRO
ФОТСЕНСИБИЛИЗАЦИЯ
НЕЖЕЛАТЕЛЬНЫЕ ЭФФЕКТЫ
ВИЧ-ИНФЕКЦИИ

Доп.точки доступа:
Utsumi, Takahiko; Okuma, Minoru; Kanno, Tomoko; Takehara, Yoshiki; Yoshioka, Tamotsu; Fujita, Yuhzo; Horton, Alan A.; Utsumi, Kozo

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