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РЖ ВИНИТИ 34 (BI48) 95.07-04Т2.274

In vitro activity of sparfloxacin (CI-978), a new broad-spectrum fluoroquinolone [Text] / S. M.Hussain Qadri [et al.] // Chemotherapy. - 1992. - Vol. 38, N 2. - P99-106 . - ISSN 0009-3157
Перевод заглавия: Активность in vitro спарфлоксацина (CI-978), нового фторхинолона широкого спектра действия
Аннотация: The in vitro activity of sparfloxacin (CI-978, АТ-4140), a new fluoroquinolone, was compared with ciprofloxacin, norfloxacin and other commonly used antimicrobial agents against 650 strains of Enterobacteriaceae, 237 isolates of other gram-negative bacilli and 318 strains of gram-positive cocci. The MICs of sparfloxacin against 90% of the members of Enterobacteriaceae were between 0.12 and 0.5 'мю'g/ml. All the 48 isolates of notoriously drug-resistant Serratia marcescens were inhibited by 0.03-4.0 'мю'g/ml of sparfloxacin. All the 90 isolates of Acinetobacter, 80 of the 88 strains of Pseudomonas aeruginosa and all the 28 isolates of Xanthomonas maltophilia were susceptible to sparfloxacin. The MIC[9][0] for all the cocci tested ranged between 0.5 and 4.0 'мю'g/ml of sparfloxacin. It ingibited 92% of enterococci as compared with 27% for ciprofloxacin and 22% for norfloxacin. It was better or comparable in activity to other fluoroquinolones and superior to penicillins, cephalosporins and aminoglycosides tested. There was cross-resistance between ciprofloxacin, norfloxacin and sparfloxacin. Саудовская Аравия, King Faisal Specialist Hospital and Research Centre, Riyadh. Библ. 16.

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.17
Рубрики: СПАРФЛОКСАЦИЯ
АКТИВНОСТЬ
СПЕКТР
IN VITRO
ФТОРХИНОЛОНЫ

Доп.точки доступа:
Qadri, S.M.Hussain; Ueno, Yoshio; Burns, J.Joyce; Almodovar, Edna; Rabea, Nada

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