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1.
РЖ ВИНИТИ 34 (BI48) 96.08-04Т1.323

   

    Age-related alterations of skeletal muscle metabolism by intermittent hypoxia and TRH-analogue treatment [Text] / O. Pastoris [et al.] // Pharmacol. Res. - 1994. - Vol. 30, N 2. - P171-185 . - ISSN 1043-6618
Перевод заглавия: Связанные с возрастом изменения метаболизма в скелетных мышцах под воздействием прерывистой гипоксии и аналогов тиролиберина
Аннотация: The characteristics of the energy metabolism were evaluated in the gastrochemius muscle from 3- and 24-month-old rats in normoxia or subjected to either mild or severe chronic (4 weeks) intermittent normobaric hypoxia. The age-related decrease in muscular glucose 6-phosphate, pyruvate and alanine concentrations and increase in citrate concentration were consistent with the age-related decreased hexokinase and increased citrate synthase activities. Ageing was characterized by a decrease in muscular creatine phosphate concentration, while the energy mediators and the energy charge potential were unchanged. The chronic (4weeks) intermittent normobaric mild and severe hypoxiainduced alterations of the components in the anaerobic glycolytic pathway, tricarboxylic acid cycle and energy storage, that were magnified in the skeletal muschle from the oldest animals. The effect of the chronic treatment with the TRH-analogue posatireline suggests that the action of central nervous system-acting drugs could also be related to their direct influence on the muscular biochemical mechanism related to the energy transduction. Италия, Univ. di Pavia, 11-27100 Pavia. Библ. 61
ГРНТИ  
ВИНИТИ 341.45.21.23.51
Рубрики: ТИРОЛИБЕРИН
АНАЛОГИ

ПОЗАТЕРИЛИН

МЕТАБОЛИЗМ

СКЕЛЕТНЫЕ МЫШЦЫ

СТАРЕНИЕ

ГИПОКСИЯ

КРЫСЫ


Доп.точки доступа:
Pastoris, O.; Dossena, M.; Arnaboldi, R.; Gorini, A.; Villa, R.F.


2.
РЖ ВИНИТИ 34 (BI48) 96.08-04Т2.152

   

    Age-related alterations of skeletal muscle metabolism by intermittent hypoxia and TRH-analogue treatment [Text] / O. Pastoris [et al.] // Pharmacol. Res. - 1994. - Vol. 30, N 2. - P171-185 . - ISSN 1043-6618
Перевод заглавия: Связанные с возрастом изменения метаболизма в скелетных мышцах под воздействием прерывистой гипоксии и аналогов тиролиберина
Аннотация: The characteristics of the energy metabolism were evaluated in the gastrochemius muscle from 3- and 24-month-old rats in normoxia or subjected to either mild or severe chronic (4 weeks) intermittent normobaric hypoxia. The age-related decrease in muscular glucose 6-phosphate, pyruvate and alanine concentrations and increase in citrate concentration were consistent with the age-related decreased hexokinase and increased citrate synthase activities. Ageing was characterized by a decrease in muscular creatine phosphate concentration, while the energy mediators and the energy charge potential were unchanged. The chronic (4weeks) intermittent normobaric mild and severe hypoxiainduced alterations of the components in the anaerobic glycolytic pathway, tricarboxylic acid cycle and energy storage, that were magnified in the skeletal muschle from the oldest animals. The effect of the chronic treatment with the TRH-analogue posatireline suggests that the action of central nervous system-acting drugs could also be related to their direct influence on the muscular biochemical mechanism related to the energy transduction. Италия, Univ. di Pavia, 11-27100 Pavia. Библ. 61
ГРНТИ  
ВИНИТИ 341.45.21.65.15.19
Рубрики: ТИРОЛИБЕРИН
АНАЛОГИ

ПОЗАТЕРИЛИН

МЕТАБОЛИЗМ

СКЕЛЕТНЫЕ МЫШЦЫ

СТАРЕНИЕ

ГИПОКСИЯ

КРЫСЫ


Доп.точки доступа:
Pastoris, O.; Dossena, M.; Arnaboldi, R.; Gorini, A.; Villa, R.F.


 




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