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РЖ ВИНИТИ 34 (BI48) 97.09-04Т2.12

Effects of dopexamine hydrochloride on calcium channels in isolated guinea pig ventricular myocytes [Text] / Wen Dun [et al.] // Meth. and Find. Exp. and Clin. Pharmacol. - 1996. - Vol. 18, N 6. - P353-357 . - ISSN 0379-0355
Перевод заглавия: Влияние допексамина гидрохлорида на кальциевые каналы в изолированных желудочковых кардиомиоцитах морской свинки
Аннотация: The mechanisms responsible for the cardiac positive inotropic effects of dopexamine hydrochloride, a combined dopamine receptor agonist at both D[1]-receptors and 'бета'[2]-adrenoceptors, were studied. The calcium channel currents were recorded using whole-cell patch clamp technique in isolated guinea pig ventricular myocytes. At a holding potential of -40 mV, cells were depolarized to 0 mV for 400 ms at a frequency of 0.2 Hz. Dopexamine hydrochloride at doses of 5, 50 and 100 'мю'M increased the verapamil-sensitive Ca{2+} inward current by 109, 147 and 194%, respectively. The effects of dopexamine hydrochloride on Ca{2+} current reached its maximum at 5 min and partially recovered after washout of the drugs. The increased Ca{2+} current induced by dopexamine hydrochloride was completely inhibited by 20 'мю'M propranolol, a 'бета'-adrenoceptor antagonist, and was not antagonized by 20 'мю'M of SCH23390, a highly selective D[1]-receptor antagonist. These results suggest that the cardiac positive inotropic effects of dopexamine hydrochloride are brought about by the increase of Ca{2+} current via stimulation of 'бета'[2]-adrenoceptors. Библ. 17

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.29.11.11.17
Рубрики: КАРДИОТОНИЧЕСКИЕ СРЕДСТВА
ДОПЕКСАМИНА ГИДРОХЛОРИД
МЕХАНИЗМ ДЕЙСТВИЯ
ПРОПРАНОЛОЛ
SCH 23390
ВХОДНОЙ СА ТОК
КАРДИОМИОЦИТЫ ЖЕЛУДОЧКА
МОРСКАЯ СВИНКА

Доп.точки доступа:
Dun, Wen; Zhao, Rong-Rui; Liang, Yong; Wu, Bo-Wei

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