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РЖ ВИНИТИ 34 (BI39) 97.01-04К1.38

Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB) [Text] / M. Shindo [et al.] // Clin. and Exp. Immunol. - 1996. - Vol. 105, N 2. - P254-259 . - ISSN 0009-9104
Перевод заглавия: Экспрессия мРНК цитокинов в печени больных первичным циррозом печени (PBC) и хроническим гепатитом B (CHB)
Аннотация: The expression of cytokine mRNA species was determined in liver biopsies from six normal subjects, 18 patients with PBC and 14 patients with hepatitis Be antigen (HBeAg)-positive CHB, using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique. cDNA, was amplified by PCR using primers specific for the coding region of seven different cytokines IL-1, IL-2, IL-4, IL-5, IL-6, interferon-gamma (IFN-'гамма'), tumour necrosis factor-alpha (TNF-'альфа'). The abundance of some cytokines (IL-2, IL-4, IL-5 and IFN-'гамма') was also estimated by semiquantitative RT-PCR. Hepatic inflammation was assessed by a semiquantitative histologic score and by amplification of mRNA for T cell receptor (TCR)-'альфа'. mRHAs for IL-1 and IL-6 were detected in only one control liver. In CHB, mRNAs for IL-1, IL-2, IL-4, IL-5 and IFN-'гамма' were detected in 43%, 60%, 80%, 20%, and 54% of biopsies, respectively. mRNA for IFN-'гамма' and IL-4 tended to be associated with severe inflammation. In five biopsies semiquantitative analyses revealed increased levels of mRNA for TCR-'альфа' and high levels of mRNA for IFN-'гамма' and IL-4. In PBC, mRNA for IFN-'гамма' was detected in 60% of biopsies, but no mRNAs for IL-1, IL-2, IL-4, IL-5, or IL-6, or for TNF-'альфа', were detected. Semiquantitative analyses revealed that absolute levels of mRNA for IFN-'гамма' tended to correlate with the severity of hepatic inflammation. Thee results suggest that: there may be fundamental differences in the roles that cytokines play in the hepatic inflammatory processes of PBC and CHB; and while hepatic IFN-'гамма' mRNA expression is not specific for PBC, IFN-'гамма' may play a prominent role in the immunopathogenesis of PBC. Нидерланды, Dept Gastrointestinal and Liver Diseases, Academ. Ziekenhuis, Univ. Amsterdam. Библ. 38

ГРНТИ	34.43.05

ВИНИТИ 341.43.05.17
Рубрики: ЦИТОКИНЫ
ИНТЕРЛЕЙКИНЫ 1, 2, 4, 5, 6
ФАКТОР НЕКРОЗА ОПУХОЛИ АЛЬФА
МРНК
ВЫЯВЛЕНИЕ В БИОПТАТАХ ПЕЧЕНИ
ПЕРВИЧНЫЙ ЦИРРОЗ ПЕЧЕНИ
ГЕПАТИТ B
ЧЕЛОВЕК

Доп.точки доступа:
Shindo, M.; Mullin, G.E.; Braun-Elwert, L.; Bergasa, N.V.; Jones, E.A.; James, S.P.

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