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РЖ ВИНИТИ 34 (BI39) 95.09-04К1.284

Renal interleukin-1 expression during endotoxemia and gram-negative septicemia in conscious rats [Text] / Zoltan Laszik [et al.] // Circ. Shock. - 1994. - Vol. 43, N 4. - P115-121 . - ISSN 0092-6213
Перевод заглавия: Экспрессия интерлейкина 1 при эндотоксемии и септицемии грамнегативными бактериями у бодрствующих крыс
Аннотация: Endotoxin-induced cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) are thought to contribute to the proinflammatory effects of endotoxin in gram-negative infections. Using a conscious rat model of sepsis, induced by intravenous challenge with LD[95] doses of endotoxin (n=24) or live Escherichia coli (E. coli) (n-24), we examined frozen sections of kidney at various intervals for evidence of IL-1 'альфа' and TNF 'альфа' expression. A transient glomerular endothelial IL-1 'альфа' expression was demonstrated at 30 and 90 min after initiation of the sepsis in both endotoxin and E. coli-treated animals using immunohistochemistry. The endothelial IL-1 'альфа' expression as determined by immunohistochemistry occurred at the same time as IL-1 'альфа' mRNA expression, as determined by Northern blot analysis. The glomerular endothelial IL-1 'альфа' expression coincided with a slight but significant increase in the number of the glomerular polymorphonuclear leukocytes as identified by naphthol AS-D chloroacetate esterase enzyme histochemical reaction. Glomerular endothelial IL-1 'альфа' expression was virtually absent by 180 and 360 min. No TNF 'альфа' expression was detected in the renal tissues at any time interval. Neither alpha-naphthyl acetate exterase-positive nor acid phosphatase-positive monocytes/macrophages were identified in the glomeruli. Our findings provide direct in vivo evidence that the IL-1 'альфа' gene product is expressed locally in the kidney by glomerular endothelial cells in this septic rat model. США, Dep. Pathol., Univ. Oklahoma Hlth Sci. Ctr., Oklahoma City. Библ. 43

ГРНТИ	34.43.37

ВИНИТИ 341.43.37.05
Рубрики: ИНТЕРЛЕЙКИН 1
ЭКСПРЕССИЯ
КЛЕТКИ ПОЧКИ
ЭНДОТОКСЕМИЯ
СЕПТИЦЕМИЯ
ГРАМ-МОТРИЦАТЕЛЬНЫЕ БАКТЕРИИ
КРЫСЫ

Доп.точки доступа:
Laszik, Zoltan; Nadasdy, Tibor; Johnson, Loranine D.; Lerner, Megan R.; Brackett, Daniel; Silva, Fred G.

РЖ ВИНИТИ 34 (BI14) 95.10-04Б4.87

Renal interleukin-1 expression during endotoxemia and gram-negative septicemia in conscious rats [Text] / Zoltan Laszik [et al.] // Circ. Shock. - 1994. - Vol. 43, N 4. - P115-121 . - ISSN 0092-6213
Перевод заглавия: Экспрессия интерлейкина 1 при эндотоксемии и септицемии грамнегативными бактериями у бодрствующих крыс
Аннотация: Endotoxin-induced cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) are thought to contribute to the proinflammatory effects of endotoxin in gram-negative infections. Using a conscious rat model of sepsis, induced by intravenous challenge with LD[95] doses of endotoxin (n=24) or live Escherichia coli (E. coli) (n-24), we examined frozen sections of kidney at various intervals for evidence of IL-1 'альфа' and TNF 'альфа' expression. A transient glomerular endothelial IL-1 'альфа' expression was demonstrated at 30 and 90 min after initiation of the sepsis in both endotoxin and E. coli-treated animals using immunohistochemistry. The endothelial IL-1 'альфа' expression as determined by immunohistochemistry occurred at the same time as IL-1 'альфа' mRNA expression, as determined by Northern blot analysis. The glomerular endothelial IL-1 'альфа' expression coincided with a slight but significant increase in the number of the glomerular polymorphonuclear leukocytes as identified by naphthol AS-D chloroacetate esterase enzyme histochemical reaction. Glomerular endothelial IL-1 'альфа' expression was virtually absent by 180 and 360 min. No TNF 'альфа' expression was detected in the renal tissues at any time interval. Neither alpha-naphthyl acetate exterase-positive nor acid phosphatase-positive monocytes/macrophages were identified in the glomeruli. Our findings provide direct in vivo evidence that the IL-1 'альфа' gene product is expressed locally in the kidney by glomerular endothelial cells in this septic rat model. США, Dep. Pathol., Univ. Oklahoma Hlth Sci. Ctr., Oklahoma City. Библ. 43

ГРНТИ	34.27.29

ВИНИТИ 341.27.29.07.13.07.07
Рубрики: ИНТЕРЛЕЙКИН 1
ЭКСПРЕССИЯ
КЛЕТКИ ПОЧКИ
ЭНДОТОКСЕМИЯ
СЕПТИЦЕМИЯ
ГРАМ-МОТРИЦАТЕЛЬНЫЕ БАКТЕРИИ
КРЫСЫ

Доп.точки доступа:
Laszik, Zoltan; Nadasdy, Tibor; Johnson, Loranine D.; Lerner, Megan R.; Brackett, Daniel; Silva, Fred G.

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