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РЖ ВИНИТИ 34 (BI48) 96.05-04Т2.324

Shivinka, N. E.
Nystatin-, mycoheptin- and levorin-induced conductance in the membrane of frog skeletal muscle fibres [Text] / N. E. Shivinka, G. Caffier // Eur. Biophys. J. - 1995. - Vol. 24, N 1. - P23-30 . - ISSN 0175-7571
Перевод заглавия: Индуцируемая нистатином, микогептином и леворином проводимость мембран волокон скелетных мышц лягушки
Аннотация: The effects of the polyene antibiotics nystatin (2*10{-5}-10{-4} mol/l), mycoheptin (1.3*10{-6}-10{-5} mol/l) and levorin (10{-8}-5*10{-5} mol/l) on isolated frog skeletal muscle fibres and whole sartorius muscles of the frog have been investigated. Cation conductance was measured under current clamp conditions using a double sucrosegap technique. Cation effluxes were studied by means of flame emission photometry. All three antibiotics increased the cation conductance and efflux rates; however, differences between the polyenes were found in the steady state values of induced cation transport at a given concentration. The values of both induced conductance g[A'БЕСКОНЕЧН'] and efflux rate constants K[A] formed the following sequence: levorinmycoheptinnystatin, demonstrating a correlation with the order of antifungal activities. The dose-response curves of lg polyene-induced cation transport against lg of antibiotic concentration in our experiments had slope values which were much lower than those in bilayers: 1.7 and 1.3 for nystatin and mycoheptin, respectively, whereas the aromatic heptaene levorin had an even smaller concentration dependence. The decline in the equilibrium conductance caused by nystatin- and mycoheptin removal was very fast (during the first minute 'тау'=0.74 and 2.39 min, respectively). In contrast, levorin-induced conductance was irreversible, It is proposed that the processes which limit the rate of channel formation are different in biological and model membranes. Россия, Inst. Cytol., RAS, Tihkoretsky pr., 4, 194064 St. Petersburg. Библ. 37

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.95.53
Рубрики: МЕМБРАННАЯ ПРОВОДИМОСТЬ
НИСТАТИН
МИКОГЕПТИН
ЛЕВОРИН
ИНДУКЦИЯ
ВОЛОКНА
МЫШЦЫ СКЕЛЕТНЫЕ
ЛЯГУШКИ

Доп.точки доступа:
Caffier, G.

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