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РЖ ВИНИТИ 34 (BI48) 96.03-04Т1.238

Bertman, L. J.
Comparison of the antinociceptive and antispastic action of (-)-baclofen after systemic and intrathecal administration in intact, acute and chronic spinal rats [Text] / L. J. Bertman, C. Advokat // Brain Res. - 1995. - Vol. 684, N 1. - P8-18 . - ISSN 0006-8993
Перевод заглавия: Сравнение антиноцицептивного и антиспастического действия (-)-баклофена после системного и интратекального введения интактным крысам и [крысам] с острой или хронической перерезкой спинного мозга
Аннотация: This study attemped to evaluate the antinociceptive and antispastic action of (-)-baclofen by incorporating the chronic spinal preparation, in which spasticity gradually develops following spinal transection. Separate groups of intact, acute (I day) or chronic (20-25 days) spinal rats were pretested on the nociceptive tail-flick (TF) assay prior to either subcutaneous (SC; 1-30 mg/kg) or intrathecal (IT; 0.1-12 'мю'g) injection of (-)-baclofen and retested at specific post-injection intervals. Hindlimb spasticity was elicited in chronic spinal rats by mechanical stimulation to the abdomen. Both responses were tested for 3 successive days to assess tolerance. Results confirmed the analgesic effect of SC and IT (-)-baclofen in intact rats. The antinociceptive effect of IT (-)-baclofen was increased in acute spinal rats. Three weeks spinalization there was a profound decrease in this response. Antinociception produced by SC (-)-baclofen was reduced in acute and chronic spinal rats compared to intact animals; but there was no difference between the acute and chronic conditions. Both routes of administration produced an antispastic effect in chronic spinal rats. There was no antinociceptive tolerance to SC administration and only minimal tolerance to IT (-)-baclofen (in intact rats); the antispastic effect did not become tolerant. A peripheral action might explain the dichotomy between SC and IT (-)-baclofen in regard to antinociception. США, Louisiana State Univ., Baton Rouge, LA 70803. Библ. 44

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.23.33
Рубрики: БАКЛОФЕН * (-)-
ПОДКОЖНОЕ ВВЕДЕНИЕ
ИНТРАТЕКАЛЬНОЕ ВВЕДЕНИЕ
АНТИНОЦИЦЕПТИВНОЕ ДЕЙСТВИЕ
АНТИСПАСТИЧЕСКОЕ ДЕЙСТВИЕ
ПЕРЕРЕЗКА СПИННОГО МОЗГА
КРЫСЫ

Доп.точки доступа:
Advokat, C.

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