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библиографическое описание	краткий	полный

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РЖ ВИНИТИ 34 (BI48) 95.10-04Т2.82

Benedi, J. M.
Oxygen active species scanvenger properties of coumarins [Text] : [Pap.] 18 Nat. Meet. Span. Soc. Pharmacol., Alicante, 2-4 nov., 1994 / J. M. Benedi, Alvarez S. Martin-Aragon, del Fresno A. M. Villar // Meth. and Find. Exp. and Clin. Pharmacol. - 1994. - Vol. 16, Suppl. n 1. - P134 . - ISSN 0379-0355
Перевод заглавия: Свойства кумаринов, как ловушек активных кислородных радикалов
Аннотация: We tested 19 coumarins for their interaction with oxygen radicals. O[2] was generated in a PMS/NADH and a pyrogallol autoxidation systems, respectively. The OH scavenging activity was tested by detection of formaldehyde produced during the oxidation of DMSO. Hepatic microsomes/NADPH system was used to generate H[2]O[2]. At 1mM concentration, o-dihydroxylated coumarins, fraxetin, esculetin, 4-methylesculetin and 4-methyldaphnetin, lowered the concentration of O[2] by 96.66'+-'0.12, 86.41'+-'0.34, 90.65'+-'0.24 and 96.45'+-'0.19% in PMS/NADH system. At 1mM concentration, fraxetin and esculetin decreased O[2] dependent autoxidation of pyrogallol by 46.88'+-'1.11 and 38.70'+-'0.39%. At 5mM concentration, formaldehyde production was inhibited by 4-hydroxycoumarin (53.11'+-'1.17%), 7-hydroxy-coumarins (fraxetin 34.80'+-'0.37, 4-methyldaphnetin 19.71'+-'0.54, escopoletin 16.85'+-'1.42, 4-methylesculetin 15.75'+-'0.32, esculin 15.02'+-'1.46 and esculetin 14.43'+-'0.92), coumarin-3-carboxilic acid (15.38'+-'0.62%) and 7-methylcoumarin (10.77'+-'0.47%). At 0.1mM concentration 4-methyldaphnetin (91.08'+-'0.76%) and fraxetin (77.07'+-'0.98%) were antioxidant on H[2]O[2] generation system. The efectiveness of fraxetin and esculetin as anti-oxidant under various conditions, suggest that these coumarins may be attractive agents for further evaluation as clinically useful anti-oxidant

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.55
Рубрики: КУМАРИНЫ
КИСЛОРОДНЫЕ РАДИКАЛЫ
ЛОВУШКИ
ФРАКГЕТИН
ЭСКУЛЕТИН
АНТИОКСИДАНТЫ

Доп.точки доступа:
Martin-Aragon, Alvarez S.; Villar, del Fresno A.M.

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

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