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РЖ ВИНИТИ 34 (BI48) 96.08-04Т2.119

Retinoic acid reduces induction of monocyte tissue factor and tissue factor/factor VIIa - dependent arterial thrombus formation [Text] / R.Marius Barstad [et al.] // Blood. - 1995. - Vol. 86, N 1. - P212-218 . - ISSN 0006-4971
Перевод заглавия: Ретиноевая кислота препятствует образованию артериальных тромбов, вызываемому моноцитарным тканевым фактором и тканевым фактором/фактором VIIa
Аннотация: Agents that downregulate the induction of monocyte/macrophage tissue factor (TF) activity may attenuate the thrombotic risk associated with mechanical restoration of vessel patency or artificial arterial grafting. 2t have been reported that induction of endothelial TF is downregulated by all-trans retinoic acid (ATRA), and that retinoids downregulate monocyte procoagulant activity (PCA). These findings led us to investigate the effect of ATRA on monocyte TF expression, and to study the effect of ATRA on monocyte-induced thrombus formation in a model system of human arterial thrombogenesis. Induction of PCA in human peripheral blood monocytes by 0.5 'мю'g/mL lipopolysaccharide (LPS) was dose dependently reduced by ATRA, reaching a reduction of 56% at 10{-5} mol/LATRA. A 38% reduction in LPS-induced TF antigen expression was observed at an ATRA concentration of 10{-6} mol/L. Adherence of monocytes to plastic cover slips also triggered induction of cellular PCA, which was inhibited by more than 80% by an anti-TF monoclonal antibody (MoAb). Inclusion of ATRA (10{-6} mol/L) reduced this PCA by 40%, and the TF antigen expression by 30%. Exposure of Thermanox adherent monocytes to flowing nonanticoagulated human blood in a parallel-plate perfusion chamber device at an arterial wall shear rate of 650 s{-1} elicited significant fibrin deposition and platelet thrombus formation. Partial interruption of this thrombus formation was achieved by 10{-6} mol/L ATRA, which reduced the fibrin deposition by 80% and platelet thrombus formation by 50%. In comparison, incubation of adherent monocytes with the anti-TF MoAb before the blood exposure, reduced the fibrin deposition by 83% and platelet thrombus volume by 75%. Thus, ATRA is an effective downregulator of monocyte TF-PCA, and may reduce thrombotic complications at sites of plaque rupture, at plaque disruption after percutaneous transluminal angioplasty procedures, or on surfaces introduced by artificial arterial grafting. Норвегия, Nycomed Bioreg AS, N-0371, Oslo. Библ. 41

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.53.11 + 341.45.21.43.09.09
Рубрики: КИСЛОТА РЕТИНОЕВАЯ
АРТЕРИАЛЬНЫЙ ТРОМБОЗ
МОНОЦИТАРНЫЙ ТКАНЕВОЙ ФАКТОР
ТКАНЕВОЙ ФАКТОР/ФАКТОР VIIA
АНТИТРОМБОТИЧЕСКОЕ ДЕЙСТВИЕ
АНГИОПЛАСТИКА
ТРОМБОТИЧЕСКИЕ ОСЛОЖНЕНИЯ

Доп.точки доступа:
Barstad, R.Marius; Hamers, Maria J.A.G.; Stephens, Ross W.; Sakariassen, Kjell S.

РЖ ВИНИТИ 34 (BI26) 96.10-04М4.492

Retinoic acid reduces induction of monocyte tissue factor and tissue factor/factor VIIa - dependent arterial thrombus formation [Text] / R.Marius Barstad [et al.] // Blood. - 1995. - Vol. 86, N 1. - P212-218 . - ISSN 0006-4971
Перевод заглавия: Ретиноевая кислота препятствует образованию артериальных тромбов, вызываемому моноцитарным тканевым фактором и тканевым фактором/фактором VIIa
Аннотация: Agents that downregulate the induction of monocyte/macrophage tissue factor (TF) activity may attenuate the thrombotic risk associated with mechanical restoration of vessel patency or artificial arterial grafting. 2t have been reported that induction of endothelial TF is downregulated by all-trans retinoic acid (ATRA), and that retinoids downregulate monocyte procoagulant activity (PCA). These findings led us to investigate the effect of ATRA on monocyte TF expression, and to study the effect of ATRA on monocyte-induced thrombus formation in a model system of human arterial thrombogenesis. Induction of PCA in human peripheral blood monocytes by 0.5 'мю'g/mL lipopolysaccharide (LPS) was dose dependently reduced by ATRA, reaching a reduction of 56% at 10{-5} mol/LATRA. A 38% reduction in LPS-induced TF antigen expression was observed at an ATRA concentration of 10{-6} mol/L. Adherence of monocytes to plastic cover slips also triggered induction of cellular PCA, which was inhibited by more than 80% by an anti-TF monoclonal antibody (MoAb). Inclusion of ATRA (10{-6} mol/L) reduced this PCA by 40%, and the TF antigen expression by 30%. Exposure of Thermanox adherent monocytes to flowing nonanticoagulated human blood in a parallel-plate perfusion chamber device at an arterial wall shear rate of 650 s{-1} elicited significant fibrin deposition and platelet thrombus formation. Partial interruption of this thrombus formation was achieved by 10{-6} mol/L ATRA, which reduced the fibrin deposition by 80% and platelet thrombus formation by 50%. In comparison, incubation of adherent monocytes with the anti-TF MoAb before the blood exposure, reduced the fibrin deposition by 83% and platelet thrombus volume by 75%. Thus, ATRA is an effective downregulator of monocyte TF-PCA, and may reduce thrombotic complications at sites of plaque rupture, at plaque disruption after percutaneous transluminal angioplasty procedures, or on surfaces introduced by artificial arterial grafting. Норвегия, Nycomed Bioreg AS, N-0371, Oslo. Библ. 41

ГРНТИ	34.39.41

ВИНИТИ 341.39.41.25.17.15
Рубрики: КИСЛОТА РЕТИНОЕВАЯ
АРТЕРИАЛЬНЫЙ ТРОМБОЗ
МОНОЦИТАРНЫЙ ТКАНЕВОЙ ФАКТОР
ТКАНЕВОЙ ФАКТОР/ФАКТОР VIIA
АНТИТРОМБОТИЧЕСКОЕ ДЕЙСТВИЕ
АНГИОПЛАСТИКА
ТРОМБОТИЧЕСКИЕ ОСЛОЖНЕНИЯ

Доп.точки доступа:
Barstad, R.Marius; Hamers, Maria J.A.G.; Stephens, Ross W.; Sakariassen, Kjell S.

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