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РЖ ВИНИТИ 34 (BI39) 96.04-04К1.722

Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus [Text] / Jeffrey S. Ginsberg [et al.] // Amer. J. Med. - 1995. - Vol. 98, N 4. - P379-388 . - ISSN 0002-9343
Перевод заглавия: Приобретенный дефицит свободного белка S связан с антифосфолипидными антителами и возрастанием образования тромбина у больных системной красной волчанкой
Аннотация: In order to determine whether there is a relationship between acquired free protein S deficiency and increased thrombin generation, were performed a study of patients with systemic lupus erythematosus (SLE). Plasma samples were assayed for free protein S and were correlated to levels of prothrombin fragments (F1 + 2); an elevated level of F1 + 2 was used as a surrogate marker for a prothrombotic state. Assays for anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) were performed on two separate blood samples taken at least 3 months apart in order to detect the presence of antiphospholipid antibodies. Of the 36 subjects, 9 had reduced free protein S levels compared to 0 of 21 controls (P = 0.01) and the mean free protein S level was significantly lower in the SLE population than in controls. Of the 24 subjects with antiphospholipid antibodies, 9 had reduced free protein S levels, compared to 0 of 12 subjects without antiphospholipid antibodies. The mean F1 + 2 level was significantly higher in study subjects with reduced free protein S levels than in those with normal free protein S levels. This study confirms an association between antiphospholipid antibodies and reduced free protein S levels and demonstrates that patients with SLE and acquired free protein S deficiency generate more thrombin than patients with SLE and normal free protein S levels. Канада, Dep. Med., McMaster Univ. Hamilton, Ont. Библ. 24

ГРНТИ	34.43.57

ВИНИТИ 341.43.57.07
Рубрики: СИСТЕМНАЯ КРАСНАЯ ВОЛЧАНКА
СНИЖЕНИЕ УРОВНЯ БЕЛКА S
АНТИФОСФОЛИПИДНЫЕ АНТИТЕЛА
СИНТЕЗ ТРОМБИНА
ЧЕЛОВЕК

Доп.точки доступа:
Ginsberg, Jeffrey S.; Demers, Christine; Brill-Edwards, Patrick; Bona, Robert; Johnston, Marilyn; Wong, Albert; Denburg, Judah A.

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