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РЖ ВИНИТИ 34 (BI48) 95.09-04Т2.83

Guillot, Richard.
Cardiovascular effects of adrenomedullin - a new hypotensive peptide isolated in humans [Text] : abstr. 88th Annu. Sci. Assem. South. Med. Assoc., Orlando, Fla, Nov. 2-6, 1994 / Richard Guillot, Howard Lippton // South. Med. J. - 1994. - Vol. 87, N 9. - S47 . - ISSN 0038-4348
Перевод заглавия: Сердечно-сосудистые эффекты адреномедуллина - нового гипотензивного пептида, выделенного у человека
Аннотация: Adrenomedullin (ADM) is a newly discovered peptide isolated from human pheochromocytoma tissue. It consists of 52 amino acids and one intramolecular disulfide bond and is homologous to calcitonin gene-related peptide (CGRP), a potent endogenous vasodilator substance. ADM is present in normal human plasma and is released exclusively by the lung, kidney, and adrenal gland. The vascular effects of intact ADM, ADM[1.52], and two ADM fragments, ADM[1.12] and ADM[13.52], were studied in vitro and in vivo using ultrasonic flow probes. ADM[1.52] and ADM[13.52] markedly relaxed isolated bovine and feline pulmonary arterial rings precontracted with U46619 (a thromboxane A[2] mimic) in an endothelial-independent manner. In the anesthetized rat, rabbit, and cat, intravenous bolus injections of ADM[1.52] and ADM[13.52], 1-30 'мю'g, decreased systemic arterial pressure in a dose-dependent manner. These prolonged systemic vasodepressor responses were accompanied by marked increases in renal blood flow and mild increases in intestinal and hindquarters blood flows. Moreover, ADM[1.52] and ADM[13.52] had marked vasodilator activity in the pulmonary vascular bed of the intact-chest cat under conditions of constant pulmonary blood flow and left atrial pressure. ADM[1.12] had no vascular activity in vitro and in vivo. Results of this study show that ADM[1.52] is a potent vasodilator substance in the lung and kidney, two organs that synthesize and release ADM. These data suggest that endothelium-derived relaxing factor does not mediate the vasorelaxant activity of ADM. These data also suggest that the vasodilator activity of the ADM molecule does not require the N terminus portion of the peptide. Since human ADM had similar vasodilator activity across species, the present data suggest that ADM may represent a new vasodilator hormone and may indicate the presence of a novel vascular control mechanism?

ГРНТИ	34.45.21

ВИНИТИ 341.45.21.29.15.02
Рубрики: АДРЕНОМЕДУЛЛИН
ПРИРОДНЫЙ ПЕПТИД
ФЕОХРОМОЦИТОМА ЧЕЛОВЕКА
ВЫДЕЛЕНИЕ
СОСУДИСТЫЙ ТОНУС
КОНТРОЛЬ
АРТЕРИАЛЬНОЕ ДАВЛЕНИЕ

Доп.точки доступа:
Lippton, Howard

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