СибНСХБ

Вид поиска

Область поиска

Найдено в других БД

Формат представления найденных документов:
библиографическое описание	краткий	полный

Поисковый запрос: (<.>S=ПРЕПАРАТ АВТ-418<.>)

Общее количество найденных документов : 1

РЖ ВИНИТИ 34 (BI48) 96.10-04Т1.94

In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes): A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation [Text] / A.David Rodrigues [et al.] // Drug Metab. and Disposit.: Biol. Fate Chem. - 1995. - Vol. 23, N 10. - P1143-1152 . - ISSN 0090-9556
Перевод заглавия: Метаболизм ABT-418 в печени шимпанзе (Pan Troglogytes) in vitro. Уникальный характер микросомального стереоселективного N'-окисления, зависимого от флавин-содержащей монооксигеназы
Аннотация: Metabolism of the cholinergic channel activator (N-methyl-{3}H]ABT-418 was studied using precision-cut tissue slices and microsomes ('+-'cytosol) prepared from a single chimpanzee liver. In both cases, the products of C-oxidation (lactam) and N'-oxidation (cistrans) were detected. In the presence of chimpanzee liver microsomes and cytosol, which had been characterized with respect to the levels of aldehyde oxidase (N{1}-methylnicotinamide oxidase), NADPH-dependent flavin-containing monooxygenase (FMO; N, N-dimethylaniline N-oxidase), and various cytochrome P450 (CYP)-dependent monooxygenase activities, ABT-418 lactam and N'-oxide formation was found to be largely dependent on CYP/aldehyde oxidase and FMO, respectively. The rank order of total (trans+cis) FMO-dependent N'-oxidation in liver microsomes was dog rat rabbit chimpanzee '=' cynomolgus monkey human. It is concluded that the metabolic profile of ABT-418 in the chimpanzee is unique. First, the C-/N'-oxidation ratio in liver slices (0.43) is similar to that of the rat and dog and dissimilar to that of the two other primate species studied; human and cynomolgus monkey (C-/N'-oxidation ratio '='9.4). Second, the pattern of ABT-418 N'-oxidation observed with chimpanzee liver microsomes, and liver slices (trans:cis=1:3), differs from that of rat, rabbit, and dog liver microsomes, rat and human kidney S-9 (transcis), human liver microsomes (trans:cis 'ЭКВИВ'1:1), and cynomolgus monkey (trans:cis 'ЭКВИВ' 2:1) liver microsomes. Lack of stereoselective N'-oxidation by human FMO was confirmed with cDNA-expressed FMO3. США, Drug Metab. Dep., Abbot Lab., Abbot Park, IL 60064-3500. Библ. 41

ГРНТИ	34.45.15

ВИНИТИ 341.45.15.09.35
Рубрики: ПРЕПАРАТ АВТ-418
МЕТАБОЛИЗМ ОКИСЛИТЕЛЬНЫЙ
МИКРОСОМЫ ПЕЧЕНИ
ОБЕЗЬЯНЫ
МОНООКСИГЕНАЗА
ФЛАВИН-СОДЕРЖАЩАЯ
ХАРАКТЕРИСТИКА

Доп.точки доступа:
Rodrigues, A.David; Kukulka, Michael J.; Ferrero, James L.; Cashman, John R.

"Электронные каталоги и базы данных библиотек СО РАН"

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)

rtvarBDview(" результаты поиска","20190607010228","4682442");

Вид поиска