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РЖ ВИНИТИ 34 (BI26) 96.08-04М4.123

Effects of lactation on the signal transduction systems regulating lipolysis in sheep subcutaneous and omental adipose tissue [Text] / Richard G. Vernon [et al.] // Biochem. J. - 1995. - Vol. 308, N 1. - P291-296 . - ISSN 0264-6021
Перевод заглавия: Влияние лактации на регулирующие липолиз системы передачи сигналов в подкожных и сальных тканях овцы
Аннотация: The effect of lactation on the regulation of lipolysis by 'бета'- and 'альфа'[2]-adrenergic agents and by adenosine has been investigated. When changes in adipocyte mean cell volume (which decreases with lactation) are allowed for, lactation increased the maximum response both to 'бета'-adrenergic agents and to the adenosine analogue N{6}-phenylisopropyladenosine, but had no apparent effect on the responsiveness of the 'альфа'[2]-adrenergic system in both subcutaneous and omental adipycytes. For subcutaneous adipocytes, there was no significant change in the number of 'бета'-adrenergic or 'альфа'[2]-adrenergic receptors, but the amount of G[s] and the maximum (forskolin-stimulated) adenylate cyclase activity were increased by lactation. In contrast, in omental adipocytes, the number of 'бета'- (but not 'альфа'[2]-) adrenergic receptors and the amount of G[s] were increased, whereas forskolin-stimulated adenylate cyclase activity was unchanged by lactation. In both types of adipocyte, cyclic AMP phosphodiesterase and total protein kinase A activities were unchanged. Lactation had no effect on the number of adenosine receptors but increased the amounts of the G[i] isoforms expressed in both types of adipocyte. These various adaptations differ markedly in a number of respects from those described previously in the rat. Lactation, then, while having a similar overall effect on the response to 'бета'-adrenergic agonists of adipocytes, achieves this by depot-specific mechanisms. In contrast, changes in response to adenosine appear to involve the same mechanism in the two depots investigated. Великобритания, Hannah Res. Inst., Ayr KA6 5HL, Scotland. Библ. 35

ГРНТИ	34.39.41

ВИНИТИ 341.39.41.07.29.02
Рубрики: ЛИПОЛИЗ
СИСТЕМА ПЕРЕДАЧИ СИГНАЛОВ
ВЛИЯНИЕ ЛАКТАЦИИ
ПОДКОЖНЫЕ И САЛЬНЫЕ ТКАНИ
ОВЦЫ

Доп.точки доступа:
Vernon, Richard G.; Doris, Rosemarie; Finley, Eric; Houslay, Miles D.; Kilgour, Elaine; Lindsay-Watt, Sylvia

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